3.6.1.66: XTP/dITP diphosphatase

This is an abbreviated version!
For detailed information about XTP/dITP diphosphatase, go to the full flat file.

Reaction

Synonyms

Af2237, dITP/XTP pyrophosphatase, Ec197, hypoxanthine/xanthine dNTP pyrophosphatase, inosine triphosphatase, inosine triphosphate pyrophosphatase, ITPA, Mj0226, PH1917, TM0159

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.66 XTP/dITP diphosphatase

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Results	in table
37330	AA Sequence
3	Cloned(Commentary)
3	Crystallization (Commentary)
4	General Information
11	kcat/KM [mM/s]
11	KM Value [mM]
2	Localization
7	Metals/Ions
11	Natural Substrates/ Products (Substrates)
15	Organism
2	Pathway
4	PDB ID
4	pH Optimum
1	pH Range
1	Protein Variants
3	Purification (Commentary)
2	Reaction
13	Reference
7	Source Tissue
37	Substrates and Products (Substrate)
7	Subunits
20	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
11	Turnover Number [1/s]

Reference

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Reference on EC 3.6.1.66 - XTP/dITP diphosphatase

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

723282

Chung, J.H.; Back, J.H.; Park, Y.I.; Han, Y.S.

Biochemical characterization of a novel hypoxanthine/xanthine dNTP pyrophosphatase from Methanococcus jannaschii

Nucleic Acids Res.

29

3099-3107

2001

Escherichia coli, Archaeoglobus fulgidus (O28046), Archaeoglobus fulgidus, Methanocaldococcus jannaschii (Q57679), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q57679)

11452035

brenda

728362

Hwang, K.Y. Chung, J.H.; Kim, S.H.; Han, Y.S.; Cho, Y.

Structure-based identification of a novel NTPase from Methanococcus jannaschii

Nat. Struct. Biol.

6

691-696

1999

Methanocaldococcus jannaschii (Q57679), Methanocaldococcus jannaschii, Methanocaldococcus jannaschii DSM 2661 (Q57679)

10404228

brenda

745548

Lokanath, N.; Pampa, K.; Takio, K.; Kunishima, N.

Structures of dimeric nonstandard nucleotide triphosphate pyrophosphatase from Pyrococcus horikoshii OT3 functional significance of interprotomer conformational changes

J. Mol. Biol.

375

1013-1025

2008

Pyrococcus horikoshii (O59580), Pyrococcus horikoshii OT-3 (O59580)

18062990

brenda

746613

Awwad, K.; Desai, A.; Smith, C.; Sommerhalter, M.

Structural and functional characterization of a noncanonical nucleoside triphosphate pyrophosphatase from Thermotoga maritima

Acta Crystallogr. Sect. D

69

184-193

2013

Thermotoga maritima (Q9WY06), Thermotoga maritima DSM 3109 (Q9WY06)

23385455

brenda

756533

Dushanov, E.; Koltovaya, N.

Effect of substitution pro32Thr on the interaction between dimer subunits of human phosphatase ITPA

Curr. Enzyme Inhib.

15

46-54

2019

Homo sapiens (Q9BY32)

-

brenda

758375

Yoneshima, Y.; Abolhassani, N.; Iyama, T.; Sakumi, K.; Shiomi, N.; Mori, M.; Shiomi, T.; Noda, T.; Tsuchimoto, D.; Nakabeppu, Y.

Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells

Sci. Rep.

6

32849

2016

Homo sapiens, Mus musculus

27618981

brenda

Entries 1 - 20 of 6

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