3.6.1.66: XTP/dITP diphosphatase
This is an abbreviated version!
For detailed information about XTP/dITP diphosphatase, go to the full flat file.
Reaction
Synonyms
Af2237, dITP/XTP pyrophosphatase, Ec197, hypoxanthine/xanthine dNTP pyrophosphatase, inosine triphosphatase, inosine triphosphate pyrophosphatase, ITPA, Mj0226, PH1917, TM0159
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General Information
General Information on EC 3.6.1.66 - XTP/dITP diphosphatase
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malfunction
physiological function
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enzyme deficiency results in cell growth suppression and DNA instability. Both growth suppression and accumulation of single-strand breaks in nuclear DNA of enzyme-deficient cells depended on MLH1/PMS2
malfunction
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enzyme deficiency results in cell growth suppression and DNA instability. Both growth suppression and accumulation of single-strand breaks in nuclear DNA of enzyme-deficient cells depended on MLH1/PMS2
the enzyme hydrolyzes the non-canonical nucleotides, dITP and XTP and may have a major role in preventing mutations caused by incorporation of dITP and XTP formed spontaneously in the nucleotide pool into DNA
physiological function
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the enzyme hydrolyzes the non-canonical nucleotides, dITP and XTP and may have a major role in preventing mutations caused by incorporation of dITP and XTP formed spontaneously in the nucleotide pool into DNA
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