3.6.1.66: XTP/dITP diphosphatase

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For detailed information about XTP/dITP diphosphatase, go to the full flat file.

Reaction

Synonyms

Af2237, dITP/XTP pyrophosphatase, Ec197, hypoxanthine/xanthine dNTP pyrophosphatase, inosine triphosphatase, inosine triphosphate pyrophosphatase, ITPA, Mj0226, PH1917, TM0159

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.66 XTP/dITP diphosphatase

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Results	in table
37330	AA Sequence
3	Cloned(Commentary)
3	Crystallization (Commentary)
4	General Information
11	kcat/KM [mM/s]
11	KM Value [mM]
2	Localization
7	Metals/Ions
11	Natural Substrates/ Products (Substrates)
15	Organism
2	Pathway
4	PDB ID
4	pH Optimum
1	pH Range
1	Protein Variants
3	Purification (Commentary)
2	Reaction
13	Reference
7	Source Tissue
37	Substrates and Products (Substrate)
7	Subunits
20	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
3	Temperature Range [°C]
2	Temperature Stability [°C]
11	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.6.1.66 - XTP/dITP diphosphatase

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystals are grown by hanging-drop vapor diffusion method, the crystal structure of the protein is determined at 2.2 A resolution

Methanocaldococcus jannaschii

Q57679

728362

oil microbatch method. High resolution crystal structures of the enzyme in two unliganded forms and in three liganded forms with the substrate ITP, the product IMP and the divalent cation Mn2+ are determined. Based on these structures, a mechanism of the divalent cation-dependent ITP hydrolysis is proposed

Pyrococcus horikoshii

O59580

745548

protein X-ray structure of the enzyme with bound IMP is obtained at 2.15 A resolution and compare it with structures of unliganded TM0159 and other noncanonical NTPases

Thermotoga maritima

Q9WY06

746613