3.6.1.6: nucleoside diphosphate phosphatase
This is an abbreviated version!
For detailed information about nucleoside diphosphate phosphatase, go to the full flat file.
Word Map on EC 3.6.1.6
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3.6.1.6
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thiamine
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apparatus
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cytochemical
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cisternae
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microglial
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cytochemistry
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saccule
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5'-nucleotidase
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glucose-6-phosphatase
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ectonucleotidases
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purinergic
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osmium
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nadpase
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monophosphatase
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ramify
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tetroxide
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ectonucleoside
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histoenzymatic
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ultracytochemical
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cmpase
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postfix
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dictyosome
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g-6-pase
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analysis
- 3.6.1.6
- thiamine
- apparatus
-
cytochemical
-
cisternae
- microglial
-
cytochemistry
-
saccule
- 5'-nucleotidase
- glucose-6-phosphatase
- ectonucleotidases
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purinergic
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osmium
- nadpase
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monophosphatase
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ramify
-
tetroxide
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ectonucleoside
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histoenzymatic
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ultracytochemical
-
cmpase
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postfix
-
dictyosome
- g-6-pase
- analysis
Reaction
Synonyms
adenosine diphosphatase, adenosinepyrophosphatase, ADPase, At3g04080, At5g18280, AtAPY1, AtAPY2, calcium activated nucleotidase 1, Cant1, CD39, CDPase, E-NTPDase1, ecto-apyrase, ecto-ATPase, ecto-nucleotidase, ectonucleoside triphosphate diphosphohydrolase, ER-UDPase, GDA1, GDPase, GDPase/UDPase, GS52, guanosine 5'-diphosphatase, guanosine diphosphatase, IDPase, inosine 5'-diphosphatase, inosine diphosphatase, lumenal ecto-nucleoside di-phosphohydrolase, lumenal NDPase, lumenal uridine diphosphatase, Lysosomal apyrase-like protein of 70 kDa, MIG-23, More, NDPase, NTPDase, NTPDase1, NTPDase1/CD39, NTPDase2, NTPDase3, NTPDase4, NTPDase5, NTPDase6, NTPDase6 (CD39L2) nucleotidase, NTPDase8, nucleoside 5'-diphosphatase, Nucleoside diphosphatase, nucleoside diphosphate phosphatase, nucleoside diphosphate phosphohydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate diphosphohydrolase-1, PAE2307, Proto-oncogene cph, SA1684, SA1684 protein, thiaminpyrophosphatase, TPPase, TTHA1091, type B nucleoside diphosphatase, type L nucleoside diphosphatase, UDA-1, UDPase
ECTree
3.6.1.6 nucleoside diphosphate phosphataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.6.1.6 - nucleoside diphosphate phosphatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ADP + H2O
AMP + phosphate
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ADPase activity of GS52 is consistently more than 1.5fold higher than the ATPase activity
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-
?
ATP + 2 H2O
AMP + 2 phosphate
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ADPase activity of GS52 is consistently more than 1.5fold higher than the ATPase activity
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-
?
ATP + 2 H2O
AMP + 2 phosphate
sequential dephosphorylation of ATP to ADP and then AMP
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-
?
CDP + H2O
CMP + phosphate
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43% of the activity with IDP, enzyme type B. 8% of the activity with IDP, enzyme type L
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?
CDP + H2O
CMP + phosphate
hydrolyzes nucleoside 5'-diphosphates in the order: UDP, GDP, IDP, GDP
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-
?
dTDP + H2O
dTMP + phosphate
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14% of the activity with IDP, type L enzyme
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?
GDP + H2O
GMP + phosphate
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95% of the activity with IDP, enzyme type B and enzyme type L
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?
GDP + H2O
GMP + phosphate
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type L enzyme chiefly works in the degradation of nucleoside diphosphates
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-
?
GDP + H2O
GMP + phosphate
hydrolyzes nucleoside 5'-diphosphates in the order: UDP, GDP, IDP, GDP
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-
?
IDP + H2O
IMP + phosphate
hydrolyzes nucleoside 5'-diphosphates in the order: UDP, GDP, IDP, GDP
-
-
?
TPP + H2O
thiamine phosphate + phosphate
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is hydrolyzed twice as efficiently as nucleoside diphosphates
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?
TPP + H2O
thiamine phosphate + phosphate
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64% of the activity with IDP, enzyme type B. 4% of the activity with IDP, enzyme type L
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?
UDP + H2O
UMP + phosphate
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59% of activity with IDP, enzyme type B. 88% of the activity with IDP, enzyme type L
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?
UDP + H2O
UMP + phosphate
hydrolyzes nucleoside 5'-diphosphates in the order: UDP, GDP, IDP, GDP
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-
?
additional information
?
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isozymes AtAPY1 and AtAPY2 appear to have a substrate preference for NDPs. AtAPY1 exhibits a clear preference towards substrate UDP, supporting previous reports indicating that it functions as UDP/GDPase
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additional information
?
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isozymes AtAPY1 and AtAPY2 appear to have a substrate preference for NDPs. AtAPY1 exhibits a clear preference towards substrate UDP, supporting previous reports indicating that it functions as UDP/GDPase
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-
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additional information
?
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isozymes AtAPY1 and AtAPY2 appear to have a substrate preference for NDPs. AtAPY2 exhibits a clear preference towards the substrate UDP/GDP, supporting previous reports indicating that it functions as UDP/GDPase
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-
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additional information
?
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isozymes AtAPY1 and AtAPY2 appear to have a substrate preference for NDPs. AtAPY2 exhibits a clear preference towards the substrate UDP/GDP, supporting previous reports indicating that it functions as UDP/GDPase
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additional information
?
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GS52 enzyme exhibits broad substrate specificity, but its activity on pyrimidine nucleotides and diphosphate nucleotides is significantly higher than on ATP due to low specificity for the adenine base within the substrate binding pocket of the enzyme. No hydrolytic activity with AMP
-
-
?
additional information
?
-
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NTPDase1 hydrolyzes ATP and ADP at a similar rate
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-
?
additional information
?
-
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the enzyme specifically binds to P2Y1 and P2Y2 receptors
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-
?
additional information
?
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the enzyme specifically binds to P2Y1 and P2Y2 receptors
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-
?
additional information
?
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NTPDase1 hydrolyzes ATP and ADP at a similar rate
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-
?
additional information
?
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the enzyme may support glycosylation reactions related to quality control in the endoplasmic reticulum
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-
?
additional information
?
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no activity with ADP, nucleoside 5'-triphosphates are hydrolyzed to a minor extend, no hydrolysis of nucleoside 5'-monophosphates
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-
?
additional information
?
-
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NTPDase1 hydrolyzes ATP and ADP at a similar rate
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-
?
additional information
?
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purified SA1684 protein has Mn2+- or Co2+-dependent hydrolyzing activity against nucleoside diphosphates. The enzyme shows or poor activity with NTPS or NMPs, substrate specificity, overview
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-
-
additional information
?
-
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purified SA1684 protein has Mn2+- or Co2+-dependent hydrolyzing activity against nucleoside diphosphates. The enzyme shows or poor activity with NTPS or NMPs, substrate specificity, overview
-
-
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additional information
?
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purified SA1684 protein has Mn2+- or Co2+-dependent hydrolyzing activity against nucleoside diphosphates. The enzyme shows or poor activity with NTPS or NMPs, substrate specificity, overview
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-
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additional information
?
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the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity
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-
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additional information
?
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the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview
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-
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additional information
?
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the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity
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-
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additional information
?
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the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview
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-
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additional information
?
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the TTHA1091 protein does not possess ADK activity but instead possesses adenosine diphosphatase (ADPase) activity
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-
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additional information
?
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the enzyme encoded by TTHA1091 shows degradation of ADP to AMP and thus possesses adenosine diphosphatase (ADPase) activity, but it does not catalyse the phosphorylation of adenosine when ATP or ADP are used as phosphate donors. The ADPase activity is specific for ADP and CDP. No or poor activity with UDP, TDP, and dCDP, substrate specificity, overview
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