3.6.1.6: nucleoside diphosphate phosphatase This is an abbreviated version! For detailed information about nucleoside diphosphate phosphatase, go to the full flat file .
Reaction
a nucleoside diphosphate +
H2O =
a nucleoside phosphate +
phosphate
Synonyms adenosine diphosphatase, adenosinepyrophosphatase, ADPase, At3g04080, At5g18280, AtAPY1, AtAPY2, calcium activated nucleotidase 1, Cant1, CD39, CDPase, E-NTPDase1, ecto-apyrase, ecto-ATPase, ecto-nucleotidase, ectonucleoside triphosphate diphosphohydrolase, ER-UDPase, GDA1, GDPase, GDPase/UDPase, GS52, guanosine 5'-diphosphatase, guanosine diphosphatase, IDPase, inosine 5'-diphosphatase, inosine diphosphatase, lumenal ecto-nucleoside di-phosphohydrolase, lumenal NDPase, lumenal uridine diphosphatase, Lysosomal apyrase-like protein of 70 kDa, MIG-23, More, NDPase, NTPDase, NTPDase1, NTPDase1/CD39, NTPDase2, NTPDase3, NTPDase4, NTPDase5, NTPDase6, NTPDase6 (CD39L2) nucleotidase, NTPDase8, nucleoside 5'-diphosphatase, Nucleoside diphosphatase, nucleoside diphosphate phosphatase, nucleoside diphosphate phosphohydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate diphosphohydrolase-1, PAE2307, Proto-oncogene cph, SA1684, SA1684 protein, thiaminpyrophosphatase, TPPase, TTHA1091, type B nucleoside diphosphatase, type L nucleoside diphosphatase, UDA-1, UDPase
ECTree
Inhibitors
Inhibitors on EC 3.6.1.6 - nucleoside diphosphate phosphatase
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1,10-phenanthroline
-
2 mM, 66% inhibition
2,2'-bipyridyl
-
2 mM, 64% inhibition
ADP
-
1 mM, 27% inhibition of thiamin-diphosphatase activity, competitive
Ca2+
about 90% inhibition at 10 mM
chlorpromazine
-
1 mM, 15% inhibition
GDP
substrate inhibition at high concentration
GDPbetaS
a non-hydrolyzable analogue of GDP
GTPgammaS
a non-hydrolyzable analogue of GTP
IMP
-
slight competitive inhibition of thiamin-diphosphatase activity
Mg2+
complete inhibition at 10 mM
Mn2+
complete inhibition at 10 mM
NEM
-
1 mM, 16% inhibition
Promethazine
-
1 mM, 15% inhibition
pyridoxal 5'-phosphate
-
1 mM, 43% inhibition of thiamin-diphosphatase activity, competitive
UDP
substrate inhibition at high concentration
AMP
-
slight competitive inhibition of thiamin-diphosphatase activity
AMP
-
0.07 mM, , 50% inhibition, type B enzyme
ATP
-
IC50 for isoenzyme 1 is 6.5 mM, IC50 for isoenzyme 2 is 4.0 mM
ATP
-
slight competitive inhibition of thiamin-diphosphatase activity
ATP
-
inhibits enzyme form A and B2 from mitochondria
diphosphate
-
complete inhibition at 1 mM, 61% inhibition at 0.06 mM
diphosphate
-
0.5 mM, 50% inhibition
EDTA
-
-
EDTA
-
complete inhibition at 1 M
EDTA
-
0.1 mM, complete inhibition
F-
-
100 mM KF, 33% inhibition
F-
-
50 mM NaF, more than 80% inhibition
H2O2
-
in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2
H2O2
-
in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2
H2O2
-
in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2
H2O2
-
in the presence of H2O2, UDPase activity is lower than that of GDPase. GDPase activity significantly decreases at high concentrations. Inverse relationship between the decline in UDPase activity and the increase in the concentration of H2O2
menadione
-
-
menadione
-
UDPase activity increases at lower concentrations of the oxidant and decreases at higher concentrations
menadione
-
UDPase activity increases at lower concentrations of the oxidant and decreases at higher concentrations
superoxide
-
GDPase activity significantly decreases at high concentrations
superoxide
-
GDPase activity significantly decreases at high concentrations
superoxide
-
GDPase activity significantly decreases at high concentrations
superoxide
-
GDPase activity significantly decreases at high concentrations
additional information
-
no inhibition by 10 mM ascorbate, 80 mM molybdate, 20 mM KF or 10 mM vanadate
-
additional information
-
GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione
-
additional information
-
GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione
-
additional information
-
GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione
-
additional information
the ADPase activity is inhibited by divalent cations
-
additional information
-
GDPase and UDPase activities are generally affected by H2O2 and the superoxide ion generated by menadione
-