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3.6.1.6: nucleoside diphosphate phosphatase

This is an abbreviated version!
For detailed information about nucleoside diphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.6

Reaction

a nucleoside diphosphate
+
H2O
=
a nucleoside phosphate
+
phosphate

Synonyms

adenosine diphosphatase, adenosinepyrophosphatase, ADPase, At3g04080, At5g18280, AtAPY1, AtAPY2, calcium activated nucleotidase 1, Cant1, CD39, CDPase, E-NTPDase1, ecto-apyrase, ecto-ATPase, ecto-nucleotidase, ectonucleoside triphosphate diphosphohydrolase, ER-UDPase, GDA1, GDPase, GDPase/UDPase, GS52, guanosine 5'-diphosphatase, guanosine diphosphatase, IDPase, inosine 5'-diphosphatase, inosine diphosphatase, lumenal ecto-nucleoside di-phosphohydrolase, lumenal NDPase, lumenal uridine diphosphatase, Lysosomal apyrase-like protein of 70 kDa, MIG-23, More, NDPase, NTPDase, NTPDase1, NTPDase1/CD39, NTPDase2, NTPDase3, NTPDase4, NTPDase5, NTPDase6, NTPDase6 (CD39L2) nucleotidase, NTPDase8, nucleoside 5'-diphosphatase, Nucleoside diphosphatase, nucleoside diphosphate phosphatase, nucleoside diphosphate phosphohydrolase, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate diphosphohydrolase 1, nucleoside triphosphate diphosphohydrolase-1, PAE2307, Proto-oncogene cph, SA1684, SA1684 protein, thiaminpyrophosphatase, TPPase, TTHA1091, type B nucleoside diphosphatase, type L nucleoside diphosphatase, UDA-1, UDPase

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.6 nucleoside diphosphate phosphatase

Inhibitors

Inhibitors on EC 3.6.1.6 - nucleoside diphosphate phosphatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
2 mM, 66% inhibition
2,2'-bipyridyl
-
2 mM, 64% inhibition
ADP
-
1 mM, 27% inhibition of thiamin-diphosphatase activity, competitive
Ca2+
about 90% inhibition at 10 mM
chlorpromazine
-
1 mM, 15% inhibition
diphosphate
GDP
substrate inhibition at high concentration
GDPbetaS
a non-hydrolyzable analogue of GDP
GTPgammaS
a non-hydrolyzable analogue of GTP
IMP
-
slight competitive inhibition of thiamin-diphosphatase activity
iodoacetamide
-
menadione
Mg2+
complete inhibition at 10 mM
Mn2+
complete inhibition at 10 mM
NEM
-
1 mM, 16% inhibition
Promethazine
-
1 mM, 15% inhibition
pyridoxal 5'-phosphate
-
1 mM, 43% inhibition of thiamin-diphosphatase activity, competitive
superoxide
UDP
substrate inhibition at high concentration
additional information
-