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evolution
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GS52 is a member of the NTPDase/apyrase family
evolution
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
evolution
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
evolution
the SA1684 gene product carries theDUF402domain, which is found in RNA-binding proteins, and has amino acid sequence similarity with a nucleoside diphosphatase, Streptomyces coelicolor SC4828 protein
evolution
the seven member Arabidopsis apyrase family contains representatives in each clade and are clustered into the AtAPY1-2 clade I (GDA1-like), the AtAPY3-6 (clade II) and AtAPY7 in clade III. The clade I (GDA-like) Arabidopsis members (AtAPY1 andAtAPY2) form a distinct clade with the other characterized plant apyrases, human apyrases and the yeast GDA1 enzyme. The protein structure of the seven Arabidopsis apyrase proteins outline the apyrase conserved domain GDA1_CD39 and predicted transmembrane helices
evolution
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the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
-
evolution
-
the SA1684 gene product carries theDUF402domain, which is found in RNA-binding proteins, and has amino acid sequence similarity with a nucleoside diphosphatase, Streptomyces coelicolor SC4828 protein
-
evolution
-
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
-
evolution
-
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
-
evolution
-
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
-
evolution
-
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
-
evolution
-
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
-
evolution
-
the enzyme is a family member of the COG1839 family, defined as adenosine-specific kinase family based on structural analysis and the adenosine-binding ability
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malfunction
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macrophages isolated from NTPDase1-null mice are devoid of all ADPase and most ATPase activities when compared with wild type macrophages. NTPDase1-null macrophages exposed to millimolar concentrations of ATP are more susceptible to cell death, release more interleukin-1beta and interleukin-18 after TLR2 or TLR4 priming, and incorporate the fluorescent dye Yo-Pro-1 more efficiently (suggestive of increased pore formation) than wild type cells
malfunction
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nucleotide hydrolysis is impaired in the wall of Entpd1-/- vessels compared with Entpd1+/+ aortas, which display significant ADPase and ATPase activity
malfunction
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the mean glial Ca2+ response to ATP was significantly larger in the presence of an NTPDase inhibitor
malfunction
enzyme knock-out mice recapitulate the desbuquois dysplasia type 1 phenotype
malfunction
immunochemical and genetic suppression of AtAPY1 and AtAPY2 results in an increase in extracellular ATP
malfunction
the SA1684-deletion mutant exhibits drastically decreased virulence in a silkworm (Bombyx mori) infection model, in which the LD50 against silkworm larvae is more than 10times that of the parent strain. The SA1684-deletion mutant also exhibits decreased exotoxin production and colony-spreading ability. Introduction of wild-type SA1684 to the SA1684-deletion mutant restores the hemolysin production, nuclease production, and the colony-spreading activity
malfunction
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the SA1684-deletion mutant exhibits drastically decreased virulence in a silkworm (Bombyx mori) infection model, in which the LD50 against silkworm larvae is more than 10times that of the parent strain. The SA1684-deletion mutant also exhibits decreased exotoxin production and colony-spreading ability. Introduction of wild-type SA1684 to the SA1684-deletion mutant restores the hemolysin production, nuclease production, and the colony-spreading activity
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malfunction
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the mean glial Ca2+ response to ATP was significantly larger in the presence of an NTPDase inhibitor
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malfunction
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nucleotide hydrolysis is impaired in the wall of Entpd1-/- vessels compared with Entpd1+/+ aortas, which display significant ADPase and ATPase activity
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metabolism
plasma membrane-bound NTPDases, namely NTPDase1/CD39, NTPDase2/CD39L1, and NTPDase8, represent the major liver ectonucleotidase activities
metabolism
roles of the Arabidopsis thaliana apyrase family in regulating endomembrane NDP/NMP homoeostasis, overview. The AtAPY1-6 Arabidopsis thaliana enzymes all exhibit classic apyrase-like NTPase and/or NDPases activities, with an absence of NMP activity
metabolism
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the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview
metabolism
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the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview
metabolism
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the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview
metabolism
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the organism shows a basic mechanism to cope with oxidative stress, suggesting that the pathogen might activate mechanisms for UDPase synthesis at lower concentrations of superoxide. Differential response to oxidative stress by different Candida species, overview
metabolism
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plasma membrane-bound NTPDases, namely NTPDase1/CD39, NTPDase2/CD39L1, and NTPDase8, represent the major liver ectonucleotidase activities
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physiological function
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NTPDase1 is the dominant ectonucleotidase responsible for the hydrolysis of ATP and ADP at the surface of mouse primary macrophages. NTPDase1 regulates P2X7-dependent responses in peritoneal macrophages
physiological function
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functional roles of NTPDase3 in association with NTPDase2 and ecto-5'-nucleotidase, in epithelial functions such as secretion and in enteric neurotransmission
physiological function
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important role for the Glycine max ecto-apyrase GS52 in rhizobial root hair infection and root nodule formation
physiological function
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NTPDase1 controls endothelial P2Y receptor-dependent relaxation, regulating both agonist level and P2 receptor reactivity. NTPDase1 differentially influences UTP and ATP responses in vivo
physiological function
the enzyme is critical for glycosaminoglycan biosynthesis in cartilage and endochondral ossification
physiological function
both AtAPY1 and AtAPY2 have been shown to play numerous physiological roles in pollen development, vegetative growth and stomata opening/closure. AtAPY1 and AtAPY2 function as plant endo-apyrases and are necessary for lumenal glycosylation. The Arabidopsis apyrases family members have possible roles in regulating endomembrane NDP/NMP (nucleoside monophosphate) homoeostasis. AtAPY 1 and AtAPY2 are able to function as internal Golgi lumenal NDPases
physiological function
RNA sequence analysis reveals thatSA1684 is required for the expression of the virulence regulatory genes agr, sarZ, and sarX, as well as metabolic genes involved in glycolysis and fermentation pathways. These findings suggest that the nucleoside diphosphatase SA1684 links metabolic pathways and virulence gene expression and plays an important role in Staphylococcus aureus virulence in silkworms. Introduction of wild-type SA1684 to the SA1684-deletion mutant restores the hemolysin production, nuclease production, and the colony-spreading activity. Enzyme SA1684 is required for hemolysin production, nuclease production, and colony spreading
physiological function
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the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties
physiological function
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the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties
physiological function
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the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties
physiological function
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the terminal processing of proteins and lipids occurs in the Golgi apparatus and involves the transport of sugar nucleotides into the Golgi lumen by specific carriers and the accumulation of nucleoside diphosphates (NDPs) as a result of oligosaccharide-protein glycosyltransferase activity. NDPs are converted into the corresponding nucleoside monophosphates (NMPs) by nucleoside diphosphatases (NDPases), thus relieving inhibition of sugar transferases. NMPs are then exchanged for equimolecular amounts of cytosolic sugar nucleotides by antiport transport systems. NDPases, commonly GDPase and UDPase, thus play a critical role in glycoprotein maturation and may influence fungal pathogenesis, morphogenesis, and cell wall properties
physiological function
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RNA sequence analysis reveals thatSA1684 is required for the expression of the virulence regulatory genes agr, sarZ, and sarX, as well as metabolic genes involved in glycolysis and fermentation pathways. These findings suggest that the nucleoside diphosphatase SA1684 links metabolic pathways and virulence gene expression and plays an important role in Staphylococcus aureus virulence in silkworms. Introduction of wild-type SA1684 to the SA1684-deletion mutant restores the hemolysin production, nuclease production, and the colony-spreading activity. Enzyme SA1684 is required for hemolysin production, nuclease production, and colony spreading
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physiological function
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functional roles of NTPDase3 in association with NTPDase2 and ecto-5'-nucleotidase, in epithelial functions such as secretion and in enteric neurotransmission
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physiological function
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NTPDase1 controls endothelial P2Y receptor-dependent relaxation, regulating both agonist level and P2 receptor reactivity. NTPDase1 differentially influences UTP and ATP responses in vivo
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additional information
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uracil nucleotides induce a strong contractile response in Entpd1-/- denuded aortic rings, ATP and ADP do not display constrictor effect at concentrations below 0.03 mM
additional information
structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG) and PAE2307 protein (PDB ID 1WVQ, from Pyrobaculum aerophilum strain ATCC 51768), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
additional information
structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
additional information
the amino acid residues Tyr88, Asp106, and Asp123/Glu124 of SA1684 protein are required for NDP hydrolysis and Staphylococcus aureus virulence
additional information
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the amino acid residues Tyr88, Asp106, and Asp123/Glu124 of SA1684 protein are required for NDP hydrolysis and Staphylococcus aureus virulence
additional information
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structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
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additional information
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the amino acid residues Tyr88, Asp106, and Asp123/Glu124 of SA1684 protein are required for NDP hydrolysis and Staphylococcus aureus virulence
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additional information
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structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
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additional information
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structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG) and PAE2307 protein (PDB ID 1WVQ, from Pyrobaculum aerophilum strain ATCC 51768), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
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additional information
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structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
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additional information
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structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
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additional information
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structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG, from Thermus thermophilus strain HB8) and PAE2307 protein (PDB ID 1WVQ), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
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additional information
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structure comparison of homologous structures of TTHA1091 protein (PDB ID 1VGG) and PAE2307 protein (PDB ID 1WVQ, from Pyrobaculum aerophilum strain ATCC 51768), overview. The model structure also suggests that the beta-phosphate group of ADP (and CDP) can be located near His80
-
additional information
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uracil nucleotides induce a strong contractile response in Entpd1-/- denuded aortic rings, ATP and ADP do not display constrictor effect at concentrations below 0.03 mM
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