3.6.1.58: 8-oxo-dGDP phosphatase

This is an abbreviated version!
For detailed information about 8-oxo-dGDP phosphatase, go to the full flat file.

Reaction

Synonyms

MTH3, MutT homologue 3, NDX-1, NUDT, NUDT5

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.58 8-oxo-dGDP phosphatase

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Results	in table
15	AA Sequence
4	Cloned(Commentary)
1	Crystallization (Commentary)
4	General Information
3	Inhibitors
5	kcat/KM [mM/s]
14	KM Value [mM]
2	Natural Substrates/ Products (Substrates)
8	Organism
1	Pathway
208	PDB ID
4	pH Optimum
1	pH Range
4	Purification (Commentary)
1	Reaction
8	Reference
24	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
6	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.6.1.58 - 8-oxo-dGDP phosphatase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

8-oxo-dGDP + H2O

8-oxo-dGMP + phosphate

Homo sapiens

Q9UKK9

NUDT5 might have a much greater role than MTH1 in preventing the occurrence of mutations that are caused by the misincorporation of 8-oxoguanine in human cells. NUDT5 has another role in promoting the MTH1 reaction, in removing its inhibitor, 8-oxo-dGDP

714834

-

-

?

8-oxo-GDP + H2O

8-oxo-GMP + phosphate

Homo sapiens

-

-

716365

-

-

?