3.6.1.57: UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase
This is an abbreviated version!
For detailed information about UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase, go to the full flat file.
Reaction
Synonyms
Cj1312, PseG, UDP-6-deoxy-AltdiNAc hydrolase, UDP-sugar hydrolase
ECTree
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Natural Substrates Products
Natural Substrates Products on EC 3.6.1.57 - UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose hydrolase
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REACTION DIAGRAM
UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O
2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + UDP
2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + UDP
the enzyme is involved in biosynthesis of pseudaminic acid (i.e. 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-nonulosonic acid). Flagella of Campylobacter jejuni are important virulence determinants, whose proper assembly and function are dependent upon glycosylation at multiple positions by sialic acid-like sugars, such as 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-L-manno-nonulosonic acid (pseudaminic acid)
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UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O
2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + UDP
the enzyme is involved in biosynthesis of pseudaminic acid (i.e. 5,7-diacetamido-3,5,7,9-tetradeoxy-L-glycero-alpha-L-manno-nonulosonic acid). The large value of the specificity constant suggests that hydrolysis of UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose is the biologically relevant reaction catalyzed by this enzyme
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UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O
2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + UDP
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UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + H2O
2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose + UDP
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