3.6.1.52: diphosphoinositol-polyphosphate diphosphatase
This is an abbreviated version!
For detailed information about diphosphoinositol-polyphosphate diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.52
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3.6.1.52
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nudix
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dipps
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diadenosine
-
pentakisphosphate
-
hexaphosphate
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mutt
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pp-insp5
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ap6a
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5-phosphoribosyl
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tetrakisphosphate
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1-pyrophosphate
- 3.6.1.52
-
nudix
- dipps
-
diadenosine
- pentakisphosphate
- hexaphosphate
-
mutt
-
pp-insp5
- ap6a
-
5-phosphoribosyl
- tetrakisphosphate
- 1-pyrophosphate
Reaction
Synonyms
5PP-IP5 phosphatase, Aps protein, D250, DDP1, diphosphoinositol phosphate phosphohydrolase, diphosphoinositol phosphohydrolase, diphosphoinositol polyphosphate phosphatase, diphosphoinositol polyphosphate phosphohydrolase, diphosphoinositol polyphosphate phosphohydrolase 1, diphosphoinositol-polyphosphate phosphohydrolase, DIPP, DIPP1, DIPP2, DIPP3, g5Rp, More, muDIPP1, phosphatase, diphosphoinositol polyphosphate, poly-P endopolyphosphatase, Siw14
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Reference
Reference on EC 3.6.1.52 - diphosphoinositol-polyphosphate diphosphatase
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Safrany, S.T.; Caffrey, J.J.; Yang, X.; Bembenek, M.E.; Moyer, M.B.; Burkhart, W.A.; Shears, S.B.
A novel context for the 'MutT' module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase
EMBO J.
17
6599-6607
1998
Homo sapiens, Rattus norvegicus
Safrany, S.T.; Ingram, S.W.; Cartwright, J.L.; Falck, J.R.; McLennan, A.G.; Barnes, L.D.; Shears, S.B.
The diadenosine hexaphosphate hydrolases from Schizosaccharomyces pombe and Saccharomyces cerevisiae are homologues of the human diphosphoinositol polyphosphate phosphohydrolase. Overlapping substrate specificities in a MutT-type protein
J. Biol. Chem.
274
21735-21740
1999
Homo sapiens
Yang, X.; Safrany, S.T.; Shears, S.B.
Site-directed mutagenesis of diphosphoinositol polyphosphate phosphohydrolase, a dual specificity NUDT enzyme that attacks diadenosine polyphosphates and diphosphoinositol polyphosphates
J. Biol. Chem.
274
35434-35440
1999
Homo sapiens
Caffrey, J.J.; Safrany, S.T.; Yang, X.; Shears, S.B.
Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding NUDT family
J. Biol. Chem.
275
12730-12736
2000
Homo sapiens
Hua, L.V.; Hidaka, K.; Pesesse, X.; Barnes, L.D.; Shears, S.B.
Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases
Biochem. J.
373
81-89
2003
Mus musculus (P0C028), Mus musculus
Hidaka, K.; Caffrey, J.J.; Hua, L.; Zhang, T.; Falck, J.R.; Nickel, G.C.; Carrel, L.; Barnes, L.D.; Shears, S.B.
An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase
J. Biol. Chem.
277
32730-32738
2002
Homo sapiens (P07202), Homo sapiens (Q96G61), Homo sapiens
Cartwright, J.L.; Safrany, S.T.; Dixon, L.K.; Darzynkiewicz, E.; Stepinski, J.; Burke, R.; McLennan, A.G.
The g5R (D250) gene of African swine fever virus encodes a Nudix hydrolase that preferentially degrades diphosphoinositol polyphosphates
J. Virol.
76
1415-1421
2002
African swine fever virus
Chu, C.; Alapat, D.; Wen, X.; Timo, K.; Burstein, D.; Lisanti, M.; Shears, S.; Kohtz, D.S.
Ectopic expression of murine diphosphoinositol polyphosphate phosphohydrolase 1 attenuates signaling through the ERK1/2 pathway
Cell. Signal.
16
1045-1059
2004
Mus musculus
Winward, L.; Whitfield, W.G.; McLennan, A.G.; Safrany, S.T.
Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch?
Int. J. Biochem. Cell Biol.
42
1174-1181
2010
Drosophila melanogaster
Lonetti, A.; Szijgyarto, Z.; Bosch, D.; Loss, O.; Azevedo, C.; Saiardi, A.
Identification of an evolutionarily conserved family of inorganic polyphosphate endopolyphosphatases
J. Biol. Chem.
286
31966-31974
2011
Homo sapiens
Wu, M.; Chong, L.S.; Capolicchio, S.; Jessen, H.J.; Resnick, A.C.; Fiedler, D.
Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analogues
Angew. Chem. Int. Ed. Engl.
53
7192-7197
2014
Homo sapiens (O95989)
Trilisenko, L.V.; Andreeva, N.A.; Eldarov, M.A.; Dumina, M.V.; Kulakovskaya, T.V.
Polyphosphates and polyphosphatase activity in the yeast Saccharomyces cerevisiae during overexpression of the DDP1 gene
Biochemistry
80
1312-1317
2015
Saccharomyces cerevisiae (Q99321), Saccharomyces cerevisiae, Saccharomyces cerevisiae ATCC 204508 (Q99321)
Steidle, E.A.; Chong, L.S.; Wu, M.; Crooke, E.; Fiedler, D.; Resnick, A.C.; Rolfes, R.J.
A novel inositol pyrophosphate phosphatase in Saccharomyces cerevisiae Siw14 protein selectively cleaves the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5)
J. Biol. Chem.
291
6772-6783
2016
Saccharomyces cerevisiae, Saccharomyces cerevisiae BY4741
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