3.6.1.52: diphosphoinositol-polyphosphate diphosphatase
This is an abbreviated version!
For detailed information about diphosphoinositol-polyphosphate diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.52
-
3.6.1.52
-
nudix
-
dipps
-
diadenosine
-
pentakisphosphate
-
hexaphosphate
-
mutt
-
pp-insp5
-
ap6a
-
5-phosphoribosyl
-
tetrakisphosphate
-
1-pyrophosphate
- 3.6.1.52
-
nudix
- dipps
-
diadenosine
- pentakisphosphate
- hexaphosphate
-
mutt
-
pp-insp5
- ap6a
-
5-phosphoribosyl
- tetrakisphosphate
- 1-pyrophosphate
Reaction
Synonyms
5PP-IP5 phosphatase, Aps protein, D250, DDP1, diphosphoinositol phosphate phosphohydrolase, diphosphoinositol phosphohydrolase, diphosphoinositol polyphosphate phosphatase, diphosphoinositol polyphosphate phosphohydrolase, diphosphoinositol polyphosphate phosphohydrolase 1, diphosphoinositol-polyphosphate phosphohydrolase, DIPP, DIPP1, DIPP2, DIPP3, g5Rp, More, muDIPP1, phosphatase, diphosphoinositol polyphosphate, poly-P endopolyphosphatase, Siw14
ECTree
Advanced search results
Engineering
Engineering on EC 3.6.1.52 - diphosphoinositol-polyphosphate diphosphatase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
E66Q
-
no significant activity towards diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate, activity with diadenosine 5',5'''-P1,P6-hexaphosphate is 2% of the activity of the wild-type enzyme
E70Q
F84Y
-
hydrolysis of bisdiphosphoinositol tetrakisphosphate at 63% of the activity of the wild-type enzyme, hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate is 75% of the activity of the wild-type enzyme, activity with diphosphoinositol pentakisphosphate is only slightly reduced
G50A
-
hydrolysis of diphosphoinositol polyphosphates is more than 85% less than that of the wild-type enzyme
G52A
-
hydrolysis of diphosphoinositol polyphosphates is more than 85% less than that of the wild-type enzyme
G72A
-
catalytic activity towards bisdiphosphoinositol tetrakisphosphate, diadenosine 5',5'''-P1,P6-hexaphosphateand diphosphoinositol pentakisphosphate is impaired by more than 95%
G75A
-
catalytic activity towards bisdiphosphoinositol tetrakisphosphate, diadenosine 5',5'''-P1,P6-hexaphosphateand diphosphoinositol pentakisphosphate is impaired by more than 95%
G78A
-
catalytic activity and CD spectrum is not significantly different from that of the wild.type enzyme
H91L
-
hydrolysis of bisdiphosphoinositol tetrakisphosphate at 4% of the activity of the wild-type enzyme, hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate is 26% of the activity of the wild-type enzyme, activity with diphosphoinositol pentakisphosphate is only slightly reduced
E70Q
-
greatly reduced rate of hydrolysis of diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate
C214S
additional information
E70Q
-
inactive against dATP,diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate
overexpression of yeast diphosphoinositol polyphosphate phosphohydrolase (DDP1) in Saccharomyces cerevisiae leads to significantly increased compared to the parent strain. The content of acid-soluble and acid-insoluble polyphosphates under DDP1 overexpression decreases by 9 and 28%, respectively
additional information
-
overexpression of yeast diphosphoinositol polyphosphate phosphohydrolase (DDP1) in Saccharomyces cerevisiae leads to significantly increased compared to the parent strain. The content of acid-soluble and acid-insoluble polyphosphates under DDP1 overexpression decreases by 9 and 28%, respectively
additional information
-
overexpression of yeast diphosphoinositol polyphosphate phosphohydrolase (DDP1) in Saccharomyces cerevisiae leads to significantly increased compared to the parent strain. The content of acid-soluble and acid-insoluble polyphosphates under DDP1 overexpression decreases by 9 and 28%, respectively
-