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3.6.1.52: diphosphoinositol-polyphosphate diphosphatase

This is an abbreviated version!
For detailed information about diphosphoinositol-polyphosphate diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.52

Reaction

diphospho-myo-inositol polyphosphate
+
H2O
=
myo-inositol polyphosphate
+
phosphate

Synonyms

5PP-IP5 phosphatase, Aps protein, D250, DDP1, diphosphoinositol phosphate phosphohydrolase, diphosphoinositol phosphohydrolase, diphosphoinositol polyphosphate phosphatase, diphosphoinositol polyphosphate phosphohydrolase, diphosphoinositol polyphosphate phosphohydrolase 1, diphosphoinositol-polyphosphate phosphohydrolase, DIPP, DIPP1, DIPP2, DIPP3, g5Rp, More, muDIPP1, phosphatase, diphosphoinositol polyphosphate, poly-P endopolyphosphatase, Siw14

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.52 diphosphoinositol-polyphosphate diphosphatase

Engineering

Engineering on EC 3.6.1.52 - diphosphoinositol-polyphosphate diphosphatase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E66Q
-
no significant activity towards diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate, activity with diadenosine 5',5'''-P1,P6-hexaphosphate is 2% of the activity of the wild-type enzyme
F84Y
-
hydrolysis of bisdiphosphoinositol tetrakisphosphate at 63% of the activity of the wild-type enzyme, hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate is 75% of the activity of the wild-type enzyme, activity with diphosphoinositol pentakisphosphate is only slightly reduced
G50A
-
hydrolysis of diphosphoinositol polyphosphates is more than 85% less than that of the wild-type enzyme
G52A
-
hydrolysis of diphosphoinositol polyphosphates is more than 85% less than that of the wild-type enzyme
G72A
-
catalytic activity towards bisdiphosphoinositol tetrakisphosphate, diadenosine 5',5'''-P1,P6-hexaphosphateand diphosphoinositol pentakisphosphate is impaired by more than 95%
G75A
-
catalytic activity towards bisdiphosphoinositol tetrakisphosphate, diadenosine 5',5'''-P1,P6-hexaphosphateand diphosphoinositol pentakisphosphate is impaired by more than 95%
G78A
-
catalytic activity and CD spectrum is not significantly different from that of the wild.type enzyme
G82A
-
mutation promotes some unraveling of the normal secondary structure
H91L
-
hydrolysis of bisdiphosphoinositol tetrakisphosphate at 4% of the activity of the wild-type enzyme, hydrolysis of diadenosine 5',5'''-P1,P6-hexaphosphate is 26% of the activity of the wild-type enzyme, activity with diphosphoinositol pentakisphosphate is only slightly reduced
P89R
codes for isoenzyme hDIPP3beta
E70Q
-
greatly reduced rate of hydrolysis of diphosphoinositol pentakisphosphate or bisdiphosphoinositol tetrakisphosphate
C214S
additional information