3.6.1.42: guanosine-diphosphatase
This is an abbreviated version!
For detailed information about guanosine-diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.42
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3.6.1.42
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charcot-marie-tooth
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neuropathy
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demyelinate
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nerve
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ganglioside-induced
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purinergic
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differentiation-associated
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ectonucleotidases
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gdpase
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apyrase
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ecto-5\'-nucleotidase
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sural
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ectonucleoside
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ntpdase3
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sh3tc2
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ecto-enzymes
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ecto-adenosine
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3.6.1.5
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ecto-ntpdase
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charcot
- 3.6.1.42
- charcot-marie-tooth
- neuropathy
-
demyelinate
- nerve
-
ganglioside-induced
-
purinergic
-
differentiation-associated
- ectonucleotidases
- gdpase
- apyrase
-
ecto-5\'-nucleotidase
-
sural
-
ectonucleoside
- ntpdase3
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sh3tc2
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ecto-enzymes
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ecto-adenosine
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3.6.1.5
- ecto-ntpdase
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charcot
Reaction
Synonyms
APY1, DIPP1, E-NTPDase, ecto-nucleoside triphosphate diphosphohydrolase, gda1p (GDA1 gene product), Gdap1, Gdp1p, GDPase, guanosine diphosphatase, KlGdap1, phosphatase, guanosine di-, UDPase
ECTree
3.6.1.42 guanosine-diphosphataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.6.1.42 - guanosine-diphosphatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
P1,P5-bis(5'-adenosyl)pentaphosphate + H2O
AMP + adenosine 5'-tetraphosphate
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reaction of EC 3.6.1.17
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?
GDP + H2O
5'-GMP + phosphate
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hydrolyzes free GDP, unable to hydrolyze GDP bound to eIF-2, eukaryotic initiation factor 2, and unable to catalyze the exchange of bound GDP with GTP even in the presence of relatively high molar excess of GTP and Met-tRNA
-
?
GDP + H2O
5'-GMP + phosphate
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possible biological function in maintaining the cellular pool of GTP-GDP
-
?
GDP + H2O
5'-GMP + phosphate
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GTP is an important steric effector in many biological systems, GDP a potent inhibitor: GDPase activity could be involved in preventing potential inhibitory levels of GDP from accumulating
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?
GDP + H2O
5'-GMP + phosphate
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PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases
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?
GDP + H2O
5'-GMP + phosphate
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PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases
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?
GDP + H2O
5'-GMP + phosphate
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PCPH and mt-PCPH proteins have intrinsic GDPase activity, are GDPases
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?
GDP + H2O
5'-GMP + phosphate
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cleaves GDP that originates from GDP-mannose after mannosylation of glycoproteins in Golgi complex
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?
GDP + H2O
5'-GMP + phosphate
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GDP is a reaction product following outer-chain mannosylation of luminal proteins and inhibitor of mannosyltransferases. It is hypothesized that GMP then returns to the cytosol. GDPase presumably serves as an essential function in processing of yeast glycoproteins
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?
GDP + H2O
5'-GMP + phosphate
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GDPase plays a role in O- and N-mannosylation of proteins such as chitinase and carboxypeptidase Y and glycosylation of external invertase and of mannosylation of inositolphosphorylceramides
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?
GDP + H2O
5'-GMP + phosphate
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GDP is known to be an inhibitor of mannosylation reactions in the Golgi lumen, removal of GDP by conversion to GMP, the latter not being an inhibitor of these reactions, would allow mannosylation to proceed
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?
GDP + H2O
5'-GMP + phosphate
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guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen
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?
GDP + H2O
GMP + phosphate
GDP hydrolysis occurs in the Golgi lumen to give GMP, which is required as antiporter for GDP-mannose transport into the Golgi lumen
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-
?
GDP + H2O
GMP + phosphate
the enzyme's GDPase activity plays a role in guanosine nucleotide sugar transport into Golgi vesicles
-
-
?
GDP + H2O
GMP + phosphate
preferred substrate in presence of Ca2+ or Mn2+
-
-
?
GDP + H2O
GMP + phosphate
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the enzyme has a main role in protein glycosylation, enzyme deficiency leads to N-glycosylation defects of invertase
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-
?
UDP + H2O
UMP + phosphate
the enzyme's UDPase activity plays a role in uridine nucleotide sugar transport into Golgi vesicles
-
-
?
UDP + H2O
UMP + phosphate
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about 21% as active with UDP compared to GDP
-
-
?
UDP + H2O
UMP + phosphate
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about 10% as active with UDP compared to GDP
-
-
?
UDP + H2O
UMP + phosphate
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in the presence of 10 mM Mn2+: 3fold activation of its activity toward UDP, but not GDP, compared to activation by 10 mM Ca2+
-
-
?
UDP + H2O
UMP + phosphate
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about 10% as active with UDP compared to GDP
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-
?
UDP + H2O
UMP + phosphate
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in the presence of 10 mM Mn2+: 3fold activation of its activity toward UDP, but not GDP, compared to activation by 10 mM Ca2+
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-
?
additional information
?
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ATP, ADP, CTP, CDP, GTP, ITO, TTP, UTP and TDP are no substrates
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-
-
additional information
?
-
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hydrolyzes free GDP, unable to hydrolyze GDP bound to eIF-2, eukaryotic initiation factor 2, and unable to catalyze the exchange of bound GDP with GTP even in the presence of relatively high molar excess of GTP and Met-tRNA
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-
?
additional information
?
-
-
only GDP and UDP are hydrolyzed, no activity with other nucleoside diphosphates and triphosphates, no activity with CDP, ADP, GTP, ATP
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-
?
additional information
?
-
physiological function, role in O- and N-glycosylation, and cell and hyphae morphogenesis, affects the cell surface charge and phosphate content, enzyme is not required for the adhesion of Candida albicans to epithelial cells, overview
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-
?
additional information
?
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physiological function, GMP and UMP are required as antiporters for guanosine and uridine nucleotide sugar transport into the Golgi lumen, involved in O-glycosylation
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-
?
additional information
?
-
-
physiological function, GMP and UMP are required as antiporters for guanosine and uridine nucleotide sugar transport into the Golgi lumen, involved in O-glycosylation
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-
?
additional information
?
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no activity with other nucleoside phosphates
-
-
?
additional information
?
-
-
no activity with other nucleoside phosphates
-
-
?
additional information
?
-
-
no or only very poor activity with other nucleotide substrates than GDP and UDP
-
-
?
additional information
?
-
-
less than 2% of maximum activity with other nucleoside di-, mono-, and triphosphates
-
-
?
additional information
?
-
-
guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen
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-
?
additional information
?
-
-
GDPase is required to complete O-glycosylation of proteins
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-
?
additional information
?
-
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GDPase not essential for cell viability and growth
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-
?
additional information
?
-
-
GDPase plays a role in O- and N-mannosylation of proteins such as chitinase and carboxypeptidase Y and glycosylation of external invertase and of mannosylation of inositolphosphorylceramides and in synthesis of cell wall
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-
?
additional information
?
-
-
GDPase plays an important role in mannosylation of proteins and lipids by regulating the amount of GDP-mannose available in Golgi lumen
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-
?
additional information
?
-
-
GDPase plays an important role in mannosylation of proteins and lipids by regulating the amount of GDP-mannose available in Golgi lumen
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-
?
additional information
?
-
-
GDPase plays an important role in mannosylation of proteins and lipids by regulating the amount of GDP-mannose available in Golgi lumen
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-
?
additional information
?
-
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necessary for Golgi-specific glycosylation reactions
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-
?
additional information
?
-
-
GDPase has an important role in glycosylation reactions in Golgi lumen
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-
?
additional information
?
-
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GDPase has an important role in glycosylation reactions in Golgi lumen
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-
?
additional information
?
-
-
GDPase has an important role in glycosylation reactions in Golgi lumen
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-
?
additional information
?
-
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less than 2% of maximum activity with other nucleoside di-, mono-, and triphosphates
-
-
?
additional information
?
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bifunctional enzyme showing GDPase and uridine diphosphatase activities in vitro
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-
?
