3.6.1.40: guanosine-5'-triphosphate,3'-diphosphate phosphatase
This is an abbreviated version!
For detailed information about guanosine-5'-triphosphate,3'-diphosphate phosphatase, go to the full flat file.
Word Map on EC 3.6.1.40
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3.6.1.40
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polyphosphate
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aeolicus
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tetraphosphate
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aquifex
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alarmone
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5'-diphosphate
- 3.6.1.40
- polyphosphate
- aeolicus
- tetraphosphate
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aquifex
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alarmone
- 5'-diphosphate
Reaction
Synonyms
CJJ81176_0377, CJJ81176_1251, exopolyphosphatase/guanosine pentaphosphate phosphohydrolase, GppA, guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase, guanosine pentaphosphatase, guanosine pentaphosphate phosphatase, guanosine pentaphosphate phosphohydrolase, guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, More, phosphatase, guanosine 5'-triphosphate 3'-diphosphate 5'-, pppGpp 5'-phosphohydrolase, pppGpp phosphohydrolase, pppGpp-5'-phosphohydrolase, PPX/GPPA enzyme, PPX1
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Reaction
Reaction on EC 3.6.1.40 - guanosine-5'-triphosphate,3'-diphosphate phosphatase
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guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate
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guanosine 5'-triphosphate 3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate
the hydrolytic base is E119, the dual specificity typical for the exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family is due to a common active site for guanosine pentaphosphate and polyphosphate hydrolysis, R22 and R267, residing in different domains, are crucial for guanosine pentaphosphate specificity as they interact with the unique 3'-ribose phosphorylation
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