3.6.1.40: guanosine-5'-triphosphate,3'-diphosphate phosphatase
This is an abbreviated version!
For detailed information about guanosine-5'-triphosphate,3'-diphosphate phosphatase, go to the full flat file.
Word Map on EC 3.6.1.40
-
3.6.1.40
-
polyphosphate
-
aeolicus
-
tetraphosphate
-
aquifex
-
alarmone
-
5'-diphosphate
- 3.6.1.40
- polyphosphate
- aeolicus
- tetraphosphate
-
aquifex
-
alarmone
- 5'-diphosphate
Reaction
Synonyms
CJJ81176_0377, CJJ81176_1251, exopolyphosphatase/guanosine pentaphosphate phosphohydrolase, GppA, guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase, guanosine pentaphosphatase, guanosine pentaphosphate phosphatase, guanosine pentaphosphate phosphohydrolase, guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, More, phosphatase, guanosine 5'-triphosphate 3'-diphosphate 5'-, pppGpp 5'-phosphohydrolase, pppGpp phosphohydrolase, pppGpp-5'-phosphohydrolase, PPX/GPPA enzyme, PPX1
ECTree
Advanced search results
General Information
General Information on EC 3.6.1.40 - guanosine-5'-triphosphate,3'-diphosphate phosphatase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
physiological function
deletion mutants of exopolyphosphatases Ppx1, and the double knockout mutant Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures
physiological function
double deletion mutants of exopolyphosphatases Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures
physiological function
-
double deletion mutants of exopolyphosphatases Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures
-
physiological function
-
deletion mutants of exopolyphosphatases Ppx1, and the double knockout mutant Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures
-