3.6.1.40: guanosine-5'-triphosphate,3'-diphosphate phosphatase

This is an abbreviated version!
For detailed information about guanosine-5'-triphosphate,3'-diphosphate phosphatase, go to the full flat file.

Reaction

Synonyms

CJJ81176_0377, CJJ81176_1251, exopolyphosphatase/guanosine pentaphosphate phosphohydrolase, GppA, guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase, guanosine pentaphosphatase, guanosine pentaphosphate phosphatase, guanosine pentaphosphate phosphohydrolase, guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, More, phosphatase, guanosine 5'-triphosphate 3'-diphosphate 5'-, pppGpp 5'-phosphohydrolase, pppGpp phosphohydrolase, pppGpp-5'-phosphohydrolase, PPX/GPPA enzyme, PPX1

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.40 guanosine-5'-triphosphate,3'-diphosphate phosphatase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
4343	AA Sequence
1	CAS Registry Number
3	Cloned(Commentary)
5	Crystallization (Commentary)
4	General Information
3	Inhibitors
6	KM Value [mM]
6	Metals/Ions
3	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
14	Organism
5	Pathway
7	PDB ID
1	pH Optimum
9	Protein Variants
5	Purification (Commentary)
2	Reaction
1	Reaction Type
12	Reference
4	Specific Activity [micromol/min/mg]
1	Storage Stability
24	Substrates and Products (Substrate)
3	Subunits
25	Synonyms
1	Systematic Name
4	Turnover Number [1/s]

General Information

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

General Information on EC 3.6.1.40 - guanosine-5'-triphosphate,3'-diphosphate phosphatase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to General Information Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

physiological function

4 entries

physiological function

Campylobacter jejuni

A0A0H3PAT6, A0A0H3PES2

deletion mutants of exopolyphosphatases Ppx1, and the double knockout mutant Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures

735334

physiological function

Campylobacter jejuni

A0A0H3PAT6, A0A0H3PES2

double deletion mutants of exopolyphosphatases Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures

735334

physiological function

Campylobacter jejuni 81-176

-

double deletion mutants of exopolyphosphatases Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures

-

physiological function

Campylobacter jejuni 81-176

-

deletion mutants of exopolyphosphatases Ppx1, and the double knockout mutant Ppx1/Ppx2 show decreased accumulation of ppGpp, an alarmone molecule. The lack of ppx gene products results in defects in motility, biofilm formation, nutrient stress survival, invasion and intracellular survival indicating that maintaining a certain level of polyphosphate is critical for Ppx genes in Campylobacter jejuni pathophysiology. Both Ppx1 and Ppx2 mutants are resistant to human complement-mediated killing. The double mutant mutant is sensitive. The serum susceptibility does not occur in the presence of MgCl2 and EGTA. The chicken serum does not have any effect on the mutants' survival. The observed serum susceptibility is not related to surface capsule and lipooligosaccharide structures

-