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3.6.1.40: guanosine-5'-triphosphate,3'-diphosphate phosphatase

This is an abbreviated version!
For detailed information about guanosine-5'-triphosphate,3'-diphosphate phosphatase, go to the full flat file.

Word Map on EC 3.6.1.40

Reaction

guanosine 5'-triphosphate 3'-diphosphate
+
H2O
=
guanosine 3',5'-bis(diphosphate)
+
phosphate

Synonyms

CJJ81176_0377, CJJ81176_1251, exopolyphosphatase/guanosine pentaphosphate phosphohydrolase, GppA, guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase, guanosine pentaphosphatase, guanosine pentaphosphate phosphatase, guanosine pentaphosphate phosphohydrolase, guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase, More, phosphatase, guanosine 5'-triphosphate 3'-diphosphate 5'-, pppGpp 5'-phosphohydrolase, pppGpp phosphohydrolase, pppGpp-5'-phosphohydrolase, PPX/GPPA enzyme, PPX1

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.40 guanosine-5'-triphosphate,3'-diphosphate phosphatase

Engineering

Engineering on EC 3.6.1.40 - guanosine-5'-triphosphate,3'-diphosphate phosphatase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Y19N
-
site-directed mutagenesis, crystal structure
D136A
the mutant shows severely reduced activity compared to the wild type enzyme
D9A
the mutant shows severely reduced activity compared to the wild type enzyme
E115A
the mutant shows severely reduced activity compared to the wild type enzyme
E143A
the mutant shows severely reduced activity compared to the wild type enzyme
D136A
-
the mutant shows severely reduced activity compared to the wild type enzyme
-
D9A
-
the mutant shows severely reduced activity compared to the wild type enzyme
-
E115A
-
the mutant shows severely reduced activity compared to the wild type enzyme
-
E143A
-
the mutant shows severely reduced activity compared to the wild type enzyme
-