3.6.1.29: bis(5'-adenosyl)-triphosphatase
This is an abbreviated version!
For detailed information about bis(5'-adenosyl)-triphosphatase, go to the full flat file.
Word Map on EC 3.6.1.29
-
3.6.1.29
-
carcinogenesis
-
heterozygosity
-
clinicopathological
-
metastasis
-
microsatellite
-
tumorigenesis
-
adenocarcinoma
-
hypermethylation
-
methylation-specific
-
neoplasia
-
precancerous
-
paraffin-embedded
-
intraepithelial
-
papillomavirus
-
polyphosphate
-
tumor-suppressor
-
preneoplastic
-
p16ink4a
-
normal-sized
-
rassf1a
-
fra16d
-
hippel-lindau
-
3.6.1.17
-
caretaker
- 3.6.1.29
- carcinogenesis
-
heterozygosity
-
clinicopathological
- metastasis
-
microsatellite
- tumorigenesis
- adenocarcinoma
-
hypermethylation
-
methylation-specific
- neoplasia
-
precancerous
-
paraffin-embedded
-
intraepithelial
- papillomavirus
- polyphosphate
-
tumor-suppressor
-
preneoplastic
- p16ink4a
-
normal-sized
-
rassf1a
-
fra16d
- hippel-lindau
-
3.6.1.17
-
caretaker
Reaction
Synonyms
Ap3A hydrolase, Ap3Aase, covalent adenylyl enzyme, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, diadenosine 5,5-P1,P3-triphosphatase, diadenosine triphosphatase, dinucleoside 5',5'''-P1,P3-triphosphate hydrolase, dinucleoside triphosphatase, dinucleoside-triphosphatase, dinucleosidetriphosphatase, Fhit, Fhit protein, FHIT protein/dinucleoside triphosphatase, fragile histidine triad, Fragile histidine triad protein, fragile HIT protein, HIT-45 protein, HIT45, tumour suppressor Fhit protein
ECTree
3.6.1.29 bis(5'-adenosyl)-triphosphataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.6.1.29 - bis(5'-adenosyl)-triphosphatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2'-deoxyadenosine 5'-phosphoimidazolide + UDP
imidazole + dA(5')p3(5')U
-
H96G mutant
-
-
?
7-benzylguanosine(5')triphospho(5')adenosine + H2O
7-benzylguanosine(5')monophosphate + 7-benzylguanosine(5')diphosphate
-
-
-
-
?
7-ethylguanosine(5')triphospho(5')adenosine + H2O
7-ethylguanosine(5')monophosphate + 7-ethylguanosine(5')diphosphate
-
-
-
-
?
7-methylguanosine(5')triphospho(5')7-methylguanosine + H2O
7-methylguanosine(5')monophosphate + 7-methylguanosine(5')diphosphate
-
-
-
-
?
7-methylguanosine(5')triphospho(5')adenosine + H2O
7-methylguanosine(5')monophosphate + ADP + AMP + 7-methylguanosine(5')diphosphate
7-methylguanosine(5')triphospho(5')cytosine + H2O
7-methylguanosine(5')monophosphate + CDP + CMP + 7-methylguanosine(5')diphosphate
-
-
-
-
?
7-methylguanosine(5')triphospho(5')guanosine + H2O
7-methylguanosine(5')monophosphate + GDP + 7-methylguanosine(5')diphosphate + GMP
7-methylguanosine(5')triphospho(5')uracil + H2O
7-methylguanosine(5')monophosphate + UDP + UMP + 7-methylguanosine(5')diphosphate
-
-
-
-
?
adenosine 5'-phosphoimidazolide + ADP
imidazole + A(5')p3(5')A
-
H96G mutant
-
-
?
adenosine 5'-phosphoimidazolide + ATP
imidazole + A(5')p4(5')A
-
H96G mutant
-
-
?
adenosine 5'-phosphoimidazolide + CDP
imidazole + A(5')p3(5')C
-
H96G mutant
-
-
?
adenosine 5'-phosphoimidazolide + GDP
imidazole + A(5')p3(5')G
-
H96G mutant
-
-
?
adenosine 5'-phosphoimidazolide + TDP
imidazole + A(5')p3(5')T
-
H96G mutant
-
-
?
adenosine 5'-phosphoimidazolide + UDP
imidazole + A(5')p3(5')U
-
H96G mutant
-
-
?
adenosine 5'-phosphoimidazolide + UTP
imidazole + A(5')p4(5')U
-
H96G mutant
-
-
?
Appp-S-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacine-3-yl) methylaminoacetyl + H2O
AMP + diphospho-S-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacine-3-yl) methylaminoacetyl
-
-
-
-
?
Appp-S-(7-diethylamino-4-methyl-3-(4-succinimidylphenyl)) coumarin + H2O
AMP + diphospho-S-(7-diethylamino-4-methyl-3-(4-succinimidylphenyl)) coumarin
-
-
-
-
?
cytosine 5'-phosphoimidazolide + UDP
imidazole + C(5')p3(5')U
-
H96G mutant
-
-
?
Gppp-S-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacine-3-yl) methylaminoacetyl + H2O
GMP + diphospho-S-(4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacine-3-yl) methylaminoacetyl
-
-
-
-
?
P1-P5-bis(5'-adenosyl) pentaphosphate + H2O
adenosine monophosphate + adenosine tetraphosphate
-
-
-
-
?
thymidine 5'-phosphoimidazolide + UDP
imidazole + T(5')p3(5')U
-
H96G mutant
-
-
?
5'-O-[amino(hydroxy)phosphoryl]adenosine + H2O
?
-
64% initial velocity of degradation
-
-
?
5'-O-[amino(hydroxy)phosphoryl]adenosine + H2O
?
-
100% initial velocity of degradationin 0.1 M potassium phosphate (pH 6.8), 5 mM MgCl2, at 30°C
-
-
?
5'-O-[amino(hydroxy)phosphoryl]adenosine + H2O
?
-
96% initial velocity of degradation
-
-
?
5'-O-[fluoro(hydroxy)phosphoryl]adenosine + H2O
?
-
19% initial velocity of degradation
-
-
?
5'-O-[fluoro(hydroxy)phosphoryl]adenosine + H2O
?
-
25% initial velocity of degradation
-
-
?
5'-O-[fluoro(hydroxy)phosphoryl]adenosine + H2O
?
-
97% initial velocity of degradation
-
-
?
5'-O-[hydroxy(sulfooxy)phosphoryl]adenosine + H2O
?
-
48% initial velocity of degradation
-
-
?
5'-O-[hydroxy(sulfooxy)phosphoryl]adenosine + H2O
?
-
65% initial velocity of degradation
-
-
?
5'-O-[hydroxy(sulfooxy)phosphoryl]adenosine + H2O
?
-
100% initial velocity of degradation
-
-
?
7-methylguanosine(5')triphospho(5')adenosine + H2O
7-methylguanosine(5')monophosphate + ADP + AMP + 7-methylguanosine(5')diphosphate
-
-
-
-
?
7-methylguanosine(5')triphospho(5')adenosine + H2O
7-methylguanosine(5')monophosphate + ADP + AMP + 7-methylguanosine(5')diphosphate
-
-
-
-
?
7-methylguanosine(5')triphospho(5')guanosine + H2O
7-methylguanosine(5')monophosphate + GDP + 7-methylguanosine(5')diphosphate + GMP
-
-
-
-
?
7-methylguanosine(5')triphospho(5')guanosine + H2O
7-methylguanosine(5')monophosphate + GDP + 7-methylguanosine(5')diphosphate + GMP
-
-
-
-
?
adenosine 5'-phosphoramidate + H2O
AMP + NH3
Q9LVM4
preferred substrate
-
-
?
adenosine 5'-phosphoramidate + H2O
AMP + NH3
Q9LVM4
no requirement for Mg2+
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + sulfate
Q9LVM4
no requirement for Mg2+, reaction of EC 3.6.2.1, adenylylsulfatase
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + sulfate
Q9LVM4
reaction of EC 3.6.2.1, adenylylsulfatase
-
-
?
adenosine 5'-phosphosulfate + H2O
AMP + sulfate
-
reaction of EC 3.6.2.1, adenylylsulfatase
-
-
?
di(7-methylguanosine) 50,50 0 0-P1,P3-triphosphate + H2O
?
-
100% initial velocity of degradation
-
-
?
di(7-methylguanosine) 50,50 0 0-P1,P3-triphosphate + H2O
?
-
8% initial velocity of degradation
-
-
?
di(7-methylguanosine) 50,50 0 0-P1,P3-triphosphate + H2O
?
-
1% initial velocity of degradation
-
-
?
diadenosine 5',5''-P1,P4-tetraphosphate + H2O
AMP + ATP
-
-
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
AMP + adenosine 5'-tetraphosphate
-
-
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
AMP + adenosine 5'-tetraphosphate
-
-
-
-
?
diadenosine 5',5''-P1,P5-pentaphosphate + H2O
AMP + adenosine 5'-tetraphosphate
-
-
-
-
?
P1,P3-bis(5'-(7-methylguanosyl))triphosphate + H2O
?
-
100% initial velocities of degradation
-
-
?
P1,P3-bis(5'-(7-methylguanosyl))triphosphate + H2O
?
-
8% initial velocities of degradation
-
-
?
P1,P3-bis(5'-(7-methylguanosyl))triphosphate + H2O
?
-
1% initial velocities of degradation
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + H2O
ADP + AMP
Q9LVM4
requirement for Mg2+
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + H2O
ADP + AMP
-
27% initial velocity of degradation
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + H2O
ADP + AMP
-
FHIT protein has been shown to function as a dinucleoside 5',5'''-P1,P3-triphosphate hydrolase, forming ADP and AMP from the Ap3A substrate. Tumor suppression by FHIT occurs in lung, gastric, and renal carcinoma-derived cell lines, with Ap3A hydrolysis by FHIT being not necessary for the tumor suppressive activity
-
-
?
P1,P3-bis(5'-adenosyl) triphosphate + H2O
ADP + AMP
-
58% initial velocity of degradation
-
-
?
P1,P3-bis(5'-adenosyl)triphosphate + H2O
ADP + AMP
-
72% initial velocity of degradation
-
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O
AMP + ATP
-
27% initial velocities of degradation
-
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O
AMP + ATP
-
58% initial velocities of degradation
-
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O
AMP + ATP
major substrate
-
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O
AMP + ATP
-
72% initial velocities of degradation
-
-
?
P1-bis(5'-adenosyl) monophosphate + H2O
?
Q9LVM4
requirement for Mg2+
-
-
?
P1-P3-bis(5'-adenosyl) triphosphate + H2O
ADP + AMP
-
-
-
-
?
P1-P3-bis(5'-adenosyl) triphosphate + H2O
ADP + AMP
-
-
-
-
?
P1-P3-bis(5'-adenosyl) triphosphate + H2O
ADP + AMP
-
highest specificity
-
-
?
P1-P3-bis(5'-adenosyl) triphosphate + H2O
ADP + AMP
-
highest specificity
-
-
?
additional information
?
-
Q9LVM4
Fhit proteins, in addition to their function as dinucleoside triphosphate hydrolases, act similarly to adenylylsulfatases and nucleoside phosphoramidases, liberating nucleoside 5'-monophosphates from such natural metabolites as adenosine 5'-phosphosulfate and adenosine 5'-phosphoramidate. Moreover, Fhits recognize synthetic nucleotides, such as adenosine 5'-O-phosphorofluoridate and adenosine 5'-O-(gamma-fluorotriphosphate), and release AMP from them, the enzyme is involved in controlling the cellular level of NpnN0', overview
-
-
?
additional information
?
-
Q9LVM4
the dinucleoside triphosphatase preferentially hydrolyzes NpppN' to an NMP and N'DP
-
-
?
additional information
?
-
-
Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines
-
-
?
additional information
?
-
-
diadenosine oligophosphates, ApnA, have emerged as putative extra- and intracellular signaling molecules implicated in the maintenance and regulation of vital cellular functions and are now considered as a new class of signal transducers. FHIT induction protects from tumor necrosis factor-related apoptosis inducing ligand-induced cell death downstream TRAIL-receptors and likely requires its dinucleoside-triphosphate hydrolase activity, overview
-
-
?
additional information
?
-
-
Fhit proteins, in addition to their function as dinucleoside triphosphate hydrolases, act similarly to adenylylsulfatases and nucleoside phosphoramidases, liberating nucleoside 5'-monophosphates from such natural metabolites as adenosine 5'-phosphosulfate and adenosine 5'-phosphoramidate. Moreover, Fhits recognize synthetic nucleotides, such as adenosine 50-O-phosphorofluoridate and adenosine 5'-O-(gamma-fluorotriphosphate), and release AMP from them, the enzyme is involved in controlling the cellular level of NpnN0', overview
-
-
?
additional information
?
-
-
the dinucleoside triphosphatase preferentially hydrolyzes NpppN' to an NMP and N'DP
-
-
?
additional information
?
-
-
the enzyme does not hydrolyze Cap 4 m7Gpppm3N6,N6,2'O, Apm2'OApm2'OCpm2N3,2'OU, m7GpppApApCpU, m7GpCH2ppG, and m7Gpppm3N6,N6,2'OApm29OA
-
-
?
additional information
?
-
-
the enzyme does not hydrolyze Cap 4 m7Gpppm3N6,N6,2'O, Apm2'OApm2'OCpm2N3,2'OU, m7GpppApApCpU, m7GpCH2ppG, and m7Gpppm3N6,N6,2'OApm29OA
-
-
?
