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3.6.1.29: bis(5'-adenosyl)-triphosphatase

This is an abbreviated version!
For detailed information about bis(5'-adenosyl)-triphosphatase, go to the full flat file.

Word Map on EC 3.6.1.29

Reaction

P1,P3-bis(5'-adenosyl) triphosphate
+
H2O
=
ADP
+
AMP

Synonyms

Ap3A hydrolase, Ap3Aase, covalent adenylyl enzyme, Diadenosine 5',5'''-P1,P3-triphosphate hydrolase, diadenosine 5,5-P1,P3-triphosphatase, diadenosine triphosphatase, dinucleoside 5',5'''-P1,P3-triphosphate hydrolase, dinucleoside triphosphatase, dinucleoside-triphosphatase, dinucleosidetriphosphatase, Fhit, Fhit protein, FHIT protein/dinucleoside triphosphatase, fragile histidine triad, Fragile histidine triad protein, fragile HIT protein, HIT-45 protein, HIT45, tumour suppressor Fhit protein

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.29 bis(5'-adenosyl)-triphosphatase

KM Value

KM Value on EC 3.6.1.29 - bis(5'-adenosyl)-triphosphatase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003 - 0.015
5'-O-[amino(hydroxy)phosphoryl]adenosine
0.003
adenosine 5'-phosphoramidate
-
pH 6.8, 30°C
0.0053 - 0.18
adenosine-5'-phospho-N-methylimidazolide
0.0062 - 0.026
adenosine-5'-phosphoimidazolide
0.0006 - 0.0046
Ap4A
0.013
Ap5A
-
-
0.212
ApCF2ppA
-
-
0.117
ApCH2ppA
-
-
0.09
ApCHFppA
-
-
0.00066 - 0.0016
P1,P3-bis(5'-adenosyl)triphosphate
0.0029 - 0.026
P1-5'-O-adenosine-P3-5'-O-adenosine triphosphate
0.001 - 0.015
P1-P3-bis(5'-adenosyl) triphosphate
0.002 - 0.04
P1-P3-bis(5'-guanosyl) triphosphate
0.025
P1-P3-bis(5'-uracyl) triphosphate
-
-
20
UDP
-
pH 7, synthesis of Ap3U by H96G mutant
additional information
additional information
steady state kinetics of the phosphorylated enzyme form
-