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3.6.1.28: thiamine-triphosphatase

This is an abbreviated version!
For detailed information about thiamine-triphosphatase, go to the full flat file.

Word Map on EC 3.6.1.28

Reaction

thiamine triphosphate
+
H2O
=
thiamine diphosphate
 +
phosphate

Synonyms

25 kDa thiamine triphosphatase, 25-kDa thiamine triphosphatase, phosphatase, thiamine tri-, thiamine triphosphatase, Thtpa, ThTPase, TTPase

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.28 thiamine-triphosphatase

Engineering

Engineering on EC 3.6.1.28 - thiamine-triphosphatase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
E63Q
reduced activity
E78K
reduced activity
E85K
reduced activity
D147A
about 30% of wild-type catalytic efficiency
D37A
about 0.5% of wild-type catalytic efficiency
E81A
about 30% of wild-type catalytic efficiency
K11A
about 15% of wild-type catalytic efficiency
K193A
about 60% of wild-type catalytic efficiency
K65A
more than 1000fold decrease in kcat value
W53A
2.5fold increase in catalytic efficiency
Y39A
about 30% of wild-type catalytic efficiency
Y79A
about 5% of wild-type catalytic efficiency
K85E
-
decreased solubility, reduced catalytic activity
additional information