3.6.1.27: undecaprenyl-diphosphate phosphatase
This is an abbreviated version!
For detailed information about undecaprenyl-diphosphate phosphatase, go to the full flat file.
Word Map on EC 3.6.1.27
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3.6.1.27
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peptidoglycan
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phosphatases
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bacitracin
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phosphatidic
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vancomycin
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cell-wall
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phosphatidylglycerol
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flippase
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pyrophosphatases
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undecaprenol
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pharmacology
- 3.6.1.27
- peptidoglycan
- phosphatases
- bacitracin
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phosphatidic
- vancomycin
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cell-wall
- phosphatidylglycerol
- flippase
- pyrophosphatases
- undecaprenol
- pharmacology
Reaction
Synonyms
bacA, BcrC, C55-isoprenyl diphosphatase, C55-isoprenyl pyrophosphatase, C55-PP phosphatase, C55-PP pyrophosphatase, Dolicholpyrophosphatase, HP0851, HupA, isoprenyl pyrophosphatase, More, PbrB, PgpB, SMU.244, Und-pp phosphatase, undecaprenyl diphosphate phosphatase, undecaprenyl pyrophosphatase, undecaprenyl pyrophosphate phosphatase, undecaprenyl-pyrophosphate phosphatase, UPP phosphatase, Upp-P, UPP-Pase, UppP, YbjG, YeiU
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General Information
General Information on EC 3.6.1.27 - undecaprenyl-diphosphate phosphatase
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malfunction
physiological function
an undecaprenyl pyrophosphate phosphatase null mutant does not show any significant growth or morphological defect, neither is its sensitivity to bacitracin affected. However, the enzyme activity in the mutant is reduced by 75%
malfunction
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enzyme deletion results in a mutant with reduced biofilm formation that is highly sensitive to bacitracin, but confers more resistance to lactococcin G
malfunction
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enzyme depletion disrupts cell envelope biogenesis in Bacillus subtilis and leads to morphological defects consistent with a failure of cell envelope synthesis and strongly activates the sigmaM-dependent cell envelope stress response
malfunction
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single uppP or bcrC enzyme deletions show no or less than 0.1% misshaped cells. In contrast, both enzyme depletions leads to a severe phenotype during exponential growth phase
malfunction
Streptococcus mutans WT UA159
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enzyme deletion results in a mutant with reduced biofilm formation that is highly sensitive to bacitracin, but confers more resistance to lactococcin G
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physiological function
mutants lacking enzymic activity show no significant changes in growth rate, colony morphology and biofilm formation. The mutants exhibit increased susceptibility to bacitracin. When the enzyme is expressed in a wild-type background, the minimum inhibitory concentration of bacitracin increases to 256 mg/L. The minimum inhibitory concentrations of cefoxitin, teicoplanin, vancomycin, gentamicin, enrofloxacin and D-cycloserine are unaltered in the mutant relative to the wild-type, as are susceptibilities to other stress agents such as glycine, lysozyme, NaCl, SDS, low and high pH, oxidative stress and ethanol
physiological function
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the enzyme BcrC is more relevant during vegetative growth while the enzyme UppP is crucial for normal sporulation. Together, enzyme forms bcrC and uppP encode the essential undecaprenyl diphosphatase function of Bacillus subtilis
physiological function
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the enzyme is essential in vivo for stomach colonization and is also involved in cationic antimicrobial peptide resistance
physiological function
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the enzyme plays important roles in cell wall biosynthesis and bacitracin resistance
physiological function
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the enzyme is essential in vivo for stomach colonization and is also involved in cationic antimicrobial peptide resistance
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physiological function
Streptococcus mutans WT UA159
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the enzyme plays important roles in cell wall biosynthesis and bacitracin resistance
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