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3.6.1.23: dUTP diphosphatase

This is an abbreviated version!
For detailed information about dUTP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.23

Reaction

dUTP
+
H2O
=
dUMP
 +
diphosphate

Synonyms

DCD-DUT, dCTP deaminase-dUTPase, dCTP deaminase:dUTPase, deoxyuridine 5'-triphosphate, deoxyuridine 5'-triphosphate nucleotide hydrolase, deoxyuridine 5'-triphosphate nucleotidohydrolase, deoxyuridine 5'-triphosphate pyrophosphatase, deoxyuridine 50-triphosphate nucleotidohydrolase, deoxyuridine 5’-triphosphate nucleotidohydrolase, deoxyuridine nucleotidohydrolase, deoxyuridine triphosphatase, deoxyuridine triphosphate nucleotidohydrolase, deoxyuridine triphosphate pyrophosphatase, deoxyuridine-5'-triphosphate nucleotidohydrolase, deoxyuridine-triphosphate pyrophosphatase, desoxyuridine 5'-triphosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, desoxyuridine-triphosphatase, DURP, DUT, DUT-N, DUT1, dUTP nucleotidohydrolase, dUTP pyrophosphatase, dUTPae, dUTPase, dUTPase-dUDPase, dUTPase-related protein, E165R, More, ORF 54, ORF8, P18, PIP4, Pr95, STSV2_30, Tb927.7.5160, U45, YncF, YosS

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.23 dUTP diphosphatase

Source Tissue

Source Tissue on EC 3.6.1.23 - dUTP diphosphatase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
of patient with acute lymphocytic leukemia
Manually annotated by BRENDA team
-
an endocrine pancreatic cell line
Manually annotated by BRENDA team
dUTPase is upregulated in human tumor cells
Manually annotated by BRENDA team
-
primary cancer, patients after surgery, expression levels of the enzyme in the primary colorectal cancer of patients with and without distant metastases, the expression level is 3fold higher in the first case, overview
Manually annotated by BRENDA team
-
amnion epithelial cells
Manually annotated by BRENDA team
-
reduced enzyme expression
Manually annotated by BRENDA team
-
regenerating, activity in rat liver begins to rise 16 h after partial hepatectomy and reaches a maximum about 24 h after the operation, rising to at least 5 to 6 times the normal level
Manually annotated by BRENDA team
-
meristem cells, high levels of dUTPase in both resting and proliferating root meristem cells. Activity increase at the G1/S boundary, remains high throughout S phase, and shows almost undetectable levels during G1 and G2
Manually annotated by BRENDA team
-
asexual stage
Manually annotated by BRENDA team
-
activity in spleens of rats made anemic by phenylhydrazine is about 30times higher than that in spleens of untreated animals
Manually annotated by BRENDA team
-
proliferative intraerythroctic
Manually annotated by BRENDA team
additional information