3.6.1.22: NAD+ diphosphatase
This is an abbreviated version!
For detailed information about NAD+ diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.22
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3.6.1.22
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5'-nucleotidase
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ectoenzyme
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phosphatidylinositol-specific
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n-acetyl-beta-glucosaminidase
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plasma-membrane
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3.1.4.1
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3.6.1.9
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synthesis
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medicine
- 3.6.1.22
- 5'-nucleotidase
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ectoenzyme
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phosphatidylinositol-specific
- n-acetyl-beta-glucosaminidase
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plasma-membrane
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3.1.4.1
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3.6.1.9
- synthesis
- medicine
Reaction
Synonyms
alkaline phosphodiesterase I, At5g20070, AtNUDX19, msm1946, MSMEG_1946, NAD diphosphatase, NAD pyrophosphatase, NAD+ diphosphatase, NAD+ pyrophosphatase, NADH pyrophosphatase, NadN, NADP pyrophosphatase, NADPH pyrophosphohydrolase, nicotinamide adenine dinucleotide pyrophosphatase, NPY1, NudC, Nudix hydrolase 19, nudx19, UshA
ECTree
3.6.1.22 NAD+ diphosphataseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.6.1.22 - NAD+ diphosphatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ethionamide-NAD+ + H2O
ethionamide-NMNH + AMP
-
-
-
?
isoniazid-NAD+ + H2O
isoniazid-NMNH + AMP
-
-
-
?
thymidine 5'-p-nitrophenylphosphate + H2O
thymidine + 4-nitrophenyl phosphate
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-
-
-
?
NAD+ + H2O
AMP + NMN
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GFG1 transcript levels are rapidly and transiently induced during both biotic stresses imposed by avirulent pathogens and abiotic stresses like ozone and osmoticum.T-DNA knock out plants of GFG1 gene, gfg1-1, exhibit pleiotropic phenotypes such as reduced size, increased levels of reactive oxygen species and NADH, microscopic cell death, constitutive expression of pathogenesis-related genes and enhanced resistance to bacterial pathogens
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-
?
NAD+ + H2O
NMN + AMP
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enzyme of the pyridine-nucleotide cycle, involved in nicotine production
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-
ir
NAD+ + H2O
NMN + AMP
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enzyme of the pyridine-nucleotide cycle, involved in nicotine production
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ir
NAD+ + H2O
NMN + AMP
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possible function in NAD transport
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ir
NADH + H2O
NMNH + AMP
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possible function in regulation of NAD+/NADH-ratio
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ir
NADH + H2O
NMNH + AMP
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possible function in regulation of NAD+/NADH-ratio
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ir
NADH + H2O
NMNH + AMP
-
possible function in regulation of NAD+/NADH-ratio
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ir
NADH + H2O
NMNH + AMP
highest activity with NADH
-
-
?
NADH + H2O
NMNH + AMP
highest activity with NADH
-
-
?
NADH + H2O
NMNH + AMP
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possible function in regulation of NAD+/NADH-ratio
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ir
NADP+ + H2O
NMN + adenosine 3',5'-diphosphate
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possible function in regulation of NADP-level
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?
additional information
?
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AtNUDX19 catalyzes the hydrolysis of NADPH, but not NADH, in vivo
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-
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additional information
?
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involved in NAD uptake and processing to nicotinamide riboside
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-
?
additional information
?
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enzyme may serve a regulatory role in modifying the inhibitory effect of ecto-NAD on T-cell activation
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?
additional information
?
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enzyme may work in the regulation of nicotinamide coenzyme concentration in the peroxisome
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-
?
