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3.6.1.22: NAD+ diphosphatase

This is an abbreviated version!
For detailed information about NAD+ diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.22

Reaction

NAD(H)
+
H2O
=
AMP
+
NMN(H)

Synonyms

alkaline phosphodiesterase I, At5g20070, AtNUDX19, msm1946, MSMEG_1946, NAD diphosphatase, NAD pyrophosphatase, NAD+ diphosphatase, NAD+ pyrophosphatase, NADH pyrophosphatase, NadN, NADP pyrophosphatase, NADPH pyrophosphohydrolase, nicotinamide adenine dinucleotide pyrophosphatase, NPY1, NudC, Nudix hydrolase 19, nudx19, UshA

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.22 NAD+ diphosphatase

Inhibitors

Inhibitors on EC 3.6.1.22 - NAD+ diphosphatase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2',5'-ADP
-
44% inhibition at concentration of 0.133 mM
3-acetylpyridine
-
20% inhibition at conentration of 0.1 M
ADP
-
21% inhibition at concentration of 0.133 mM
ATP
-
22% inhibition at concentration of 0.066 mM
Co2+
-
40% inhibition of the purified enzyme at concentration of 0.33 mM, activity in crude extract not affected
CoA
-
85% inhibition at concentration of 0.133 mM
CTP
-
55% inhibition at concentration of 0.066 mM
DNA
-
strong inhibition by denaturated DNA, slight inhibition by native DNA
EDTA
-
87% inhibition, reactivation by Mn2+ or Co2+
FAD
-
35% inhibition at concentration of 0.133 mM
GTP
-
53% inhibition at concentration of 0.066 mM
Mg2+
no activity in the presence of Mg2+
NMNH
-
competitive inhibitor with Ki: 4.2 mM, no inhibition with NMN+
RNA
-
strong inhibition
UDP
-
32% inhibition at concentration of 0.133 mM
UTP
-
36% inhibition at concentration of 0.066 mM