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3.6.1.18: FAD diphosphatase

This is an abbreviated version!
For detailed information about FAD diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.18

Reaction

FAD
+
H2O
=
AMP
+
FMN

Synonyms

5'-nucleotidase, FAD diphosphatase, FAD pyrophosphatase, FADppase, flavin adenine dinucleotide pyrophosphatase, flavine adenine dinucleotide pyrophosphatase, Ftp_Ec, Ftp_Tp-like, metal-dependent FAD pyrophosphatase, Mg2+-dependent FAD pyrophosphatase, More, nucleotide phosphodiesterase, nucleotide pyrophosphatase, riboflavin adenine dinucleotide pyrophosphatase, riboflavine adenine dinucleotide pyrophosphatase, TP0796

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.18 FAD diphosphatase

Disease

Disease on EC 3.6.1.18 - FAD diphosphatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Ankylosis
Antagonistic interactions between osterix and pyrophosphate during cementum formation.
Renal calcium stones: insights from the control of bone mineralization.
Cholestasis
Serum alkaline phosphatase, nucleotide pyrophosphatase, 5'-nucleotide and lipoprotein-X in cholestasis.
Cholestasis, Extrahepatic
Usefulness of serum nucleotide pyrophosphatase and phosphodiesterase I activities in classifying liver disease.
Confusion
Purification of a plant nucleotide pyrophosphatase as a protein that interferes with nitrate reductase and glutamine synthetase assays.
Diabetes Mellitus, Type 2
The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.
Glioma
An ecto-nucleotide pyrophosphatase is one of the main enzymes involved in the extracellular metabolism of ATP in rat C6 glioma.
Hypophosphatasia
Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.
Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice.
Liver Diseases
Nucleotide pyrophosphatase and phosphodiesterase I. Demonstration of activity in normal serum, and an increase in cholestatic liver disease.
Usefulness of serum nucleotide pyrophosphatase and phosphodiesterase I activities in classifying liver disease.
Lymphoma
[Demonstration of nucleotide pyrophosphatase and phosphohydrolase activities in normal lymphocyte of Balb/c mice and absence of these activities in YC8 tumor cells and in lymphocytes of animals with YC8 lymphoma]
Neoplasms
Cancer therapy: Targeting the poison within.
Plasma membrane associated enzymes of mammary tumours as the biochemical indicators of metastasizing capacity. Analyses of enriched plasma membrane preparations.
Specific requirements for Vgamma9Vdelta2 T cell stimulation by a natural adenylated phosphoantigen.
[Demonstration of nucleotide pyrophosphatase and phosphohydrolase activities in normal lymphocyte of Balb/c mice and absence of these activities in YC8 tumor cells and in lymphocytes of animals with YC8 lymphoma]
Ossification of Posterior Longitudinal Ligament
The extent of ossification of posterior longitudinal ligament of the spine associated with nucleotide pyrophosphatase gene and leptin receptor gene polymorphisms.
Osteoarthritis
Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice.
Plasmacytoma
Identification of nucleotide pyrophosphatase/alkaline phosphodiesterase I activity associated with the mouse plasma cell differentiation antigen PC-1.
Modulation of nucleotide pyrophosphatase in plasmacytoma cells.
Spondylitis, Ankylosing
Decrease in serum nucleotide pyrophosphatase activity in ankylosing spondylitis.
Syphilis
Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm.