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3.6.1.12: dCTP diphosphatase

This is an abbreviated version!
For detailed information about dCTP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.12

Reaction

dCTP
+
H2O
=
dCMP
 +
diphosphate

Synonyms

all-alpha dCTP pyrophosphatase 1, all-alpha NTP pyrophosphatase, all-alpha nucleoside triphosphate pyrophosphatase, dCTP pyrophosphatase, dCTP pyrophosphatase 1, dCTPase, dCTPase 1, dCTPase-dUTPase, DCTPP1, deoxy-CTPase, deoxycytidine triphosphatase, deoxycytidine-triphosphatase, NTP pyrophosphatase, NTP pyrophosphohydrolase, phosphatase, deoxycytidine, tri-, pyrophosphohydrolase, RS21-C6, XTP3-TPA, XTP3-transactivated protein A, XTP3TPA

ECTree

     3 Hydrolases
         3.6 Acting on acid anhydrides
             3.6.1 In phosphorus-containing anhydrides
                3.6.1.12 dCTP diphosphatase

Disease

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Disease on EC 3.6.1.12 - dCTP diphosphatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenoma
Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients.
Breast Neoplasms
DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway.
Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation.
Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT.
Carcinoma
dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas.
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Chondrocalcinosis
Partial characterization of synovial fluid nucleotide pyrophosphohydrolase.
Pyrophosphohydrolase activity and inorganic pyrophosphate content of cultured human skin fibroblasts. Elevated levels in some patients with calcium pyrophosphate dihydrate deposition disease.
Colorectal Neoplasms
Oxidative stress and 8-oxoguanine repair are enhanced in colon adenoma and carcinoma patients.
dctp diphosphatase deficiency
Erythrocyte ITP pyrophosphohydrolase deficiency in a psychiatric population.
Further evidence for a 'new' purine defect, inosine triphosphate (ITP) pyrophosphohydrolase deficiency.
Purine metabolism in normal and high-ITP human erythrocytes. Attempts to evaluate the ability to store the cells.
The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.
Down Syndrome
Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT.
Esophageal Neoplasms
dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas.
hypoxanthine phosphoribosyltransferase deficiency
Erythrocyte ITP pyrophosphohydrolase deficiency in a psychiatric population.
Infections
Deoxycytidine triphosphatase, an enzyme induced by bacteriophage infection.
Partial exclusion of bacteriophage T2 by bacteriophage T4: induction of early enzymes by excluded T2.
Synthesis of functional bacteriophage T4-delayed early mRNA in the absence of protein synthesis.
Joint Diseases
Adenosine triphosphate pyrophosphohydrolase and neutral inorganic pyrophosphatase in pathologic joint fluids. Elevated pyrophosphohydrolase in calcium pyrophosphate dihydrate crystal deposition disease.
Partial characterization of synovial fluid nucleotide pyrophosphohydrolase.
Leukemia
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Neoplasms
Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer.
dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas.
DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically.
DCTPP1, an Oncogene Regulated by miR-378a-3p, Promotes Proliferation of Breast Cancer via DNA Repair Signaling Pathway.
Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions.
Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1.
Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation.
Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1.
New Tripodal, "Supercharged" Analogues of Adenosine Nucleotides: Inhibitors for the Fhit Ap3 A Hydrolase.
Piperazin-1-ylpyridazine Derivatives Are a Novel Class of Human dCTP Pyrophosphatase 1 Inhibitors.
Neuroblastoma
Prognostic significance of MYCN related genes in pediatric neuroblastoma: a study based on TARGET and GEO datasets.
Osteoarthritis
Partial characterization of synovial fluid nucleotide pyrophosphohydrolase.
Prostatic Neoplasms
Autophagy induced by overexpression of DCTPP1 promotes tumor progression and predicts poor clinical outcome in prostate cancer.
Stomach Neoplasms
Comparative proteomics analysis of gastric cancer stem cells.
DCTPP1 attenuates the sensitivity of human gastric cancer cells to 5-fluorouracil by up-regulating MDR1 expression epigenetically.
Vascular Calcification
[Mechanism of vascular calcification]
Whooping Cough
Substrate specificity of the pyrophosphohydrolase LpxH determines the asymmetry of Bordetella pertussis lipid A.