3.6.1.11: exopolyphosphatase This is an abbreviated version! For detailed information about exopolyphosphatase, go to the full flat file .
Reaction
(Polyphosphate)n +
H2O =
(polyphosphate)n-1 +
phosphate
Synonyms 40 kD exopolyphosphatase, 40-kDa-exopolyphosphatase, acid phosphoanhydride phosphohydrolase, CJJ81176_0377, CJJ81176_1251, CT0099, CT1713, ecPpx, exopoly(P)ase, ExopolyPase, exopolyphosphatase, exopolyphosphatase 1, exopolyphosphatase 2, Gra-Pase, h-prune, high molecular mass exopolyphosphatase, high molecular weight exopolyphosphatase, high-molecular exopolyphosphatase, LmPPX, major cytosolic exopolyphosphatase PPX1, membrane-bound exopolyphosphatase, metaphosphatase, More, Msed_0981, MT0516, NMB1467, nuclear exopolyphosphatase, Nudix hydrolase, paPpx, phosphatase, exopoly-, polyphosphate phosphatase, polyphosphate phosphohydrolase, polyphosphate-phosphohydrolase, Ppn1, PPX, Ppx protein, Ppx/GppA phosphatase, PPX1, PPX2, PPXI, PPXMsed, Rv0496, Tb927.5.4350, Tb927.6.2670, TbDcp2, TbNH2, TbNH4, vacuolar exopolyphosphatase, YHR201C, Za10_0559, ZmPPX
ECTree
Localization
Localization on EC 3.6.1.11 - exopolyphosphatase
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209849 , 654785 , 654839 , 654886 , 667750 , 667765 , 668027 , 670176 , 670725 , 685307 , 687678 , 688364 , 696170 brenda
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PPN1
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appears in the cytosol under PPX1 inactivation
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42% of the activity in the lysate
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PPN1
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soluble fraction
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PPN1
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PPN1
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nuclear exopolyphosphatase activity does not depend on the growth phase
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PPN1
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PPN1
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PPN1
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20% of the activity in the lysate
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PPN1
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additional information
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no activity in the nuclear fraction
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additional information
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existence of 2 different PPX isoforms operating in the nuclei and mitochondria with distinct metal dependence, inhibitor and activator sensitivities
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additional information
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polyP metabolism in cytosol and mitochondria is substantially dependent on the carbon source, acid-soluble polyP accumulates mainly in cytosol using either glucose or ethanol. The level of the accumulation is lower during growth on ethanol compared to that on glucose. Increase in polyP content in mitochondria occurs during growth on glucose, but not on ethanol. In cytosol the activity of exopolyphosphatase PPN1 is increased and the activity of exopolyphosphatase PPX1 is decreased independently of the carbon source under phosphate surplus conditions, overview. Growth on ethanol induces exopolyphosphatase PPN1 in the soluble mitochondrial fraction, while during growth on glucose only exopolyphosphatase PPX1 is present in this fraction
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