3.6.1.11: exopolyphosphatase

This is an abbreviated version!
For detailed information about exopolyphosphatase, go to the full flat file.

Reaction

Synonyms

40 kD exopolyphosphatase, 40-kDa-exopolyphosphatase, acid phosphoanhydride phosphohydrolase, CJJ81176_0377, CJJ81176_1251, CT0099, CT1713, ecPpx, exopoly(P)ase, ExopolyPase, exopolyphosphatase, exopolyphosphatase 1, exopolyphosphatase 2, Gra-Pase, h-prune, high molecular mass exopolyphosphatase, high molecular weight exopolyphosphatase, high-molecular exopolyphosphatase, LmPPX, major cytosolic exopolyphosphatase PPX1, membrane-bound exopolyphosphatase, metaphosphatase, More, Msed_0981, MT0516, NMB1467, nuclear exopolyphosphatase, Nudix hydrolase, paPpx, phosphatase, exopoly-, polyphosphate phosphatase, polyphosphate phosphohydrolase, polyphosphate-phosphohydrolase, Ppn1, PPX, Ppx protein, Ppx/GppA phosphatase, PPX1, PPX2, PPXI, PPXMsed, Rv0496, Tb927.5.4350, Tb927.6.2670, TbDcp2, TbNH2, TbNH4, vacuolar exopolyphosphatase, YHR201C, Za10_0559, ZmPPX

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.11 exopolyphosphatase

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Results	in table
20	Activating Compound
12781	AA Sequence
1	CAS Registry Number
25	Cloned(Commentary)
4	Crystallization (Commentary)
35	Disease/ Diagnostics
7	Expression
48	General Information
7	General Stability
15	IC50 Value
118	Inhibitors
23	kcat/KM [mM/s]
7	Ki Value [mM]
111	KM Value [mM]
58	Localization
111	Metals/Ions
44	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
110	Organism
5	Pathway
46	PDB ID
31	pH Optimum
8	pH Range
7	pH Stability
1	pI Value
1	Posttranslational Modification
52	Protein Variants
30	Purification (Commentary)
4	Reaction
12	Reaction Type
90	Reference
11	Source Tissue
64	Specific Activity [micromol/min/mg]
11	Storage Stability
219	Substrates and Products (Substrate)
30	Subunits
167	Synonyms
1	Systematic Name
17	Temperature Optimum [°C]
3	Temperature Range [°C]
8	Temperature Stability [°C]
69	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.6.1.11 - exopolyphosphatase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.163 - 0.33

(phosphate)25

2 entries

-

0.055 - 0.12

(phosphate)45

2 entries

-

0.064 - 0.105

(phosphate)65

2 entries

-

1.2 - 5.7

diphosphate

2 entries

1

hydrogen peroxide

Rhipicephalus microplus

-

in 50 mM Tris-HCl buffer (pH 7.2), at 28°C

719614

0.0019 - 0.0072

nm23-H1

2 entries

-

0.0213

Zn2+

Trypanosoma brucei

Q7Z032

in 50 mM HEPES, pH 7.8, 0.05 mM EGTA,1 mM MgCl2, at 30°C

711604

0.032

ZnCl2

Homo sapiens

-

2 mM Mg2+, hydrolysis of triphospate is inhibited

696296

additional information

heparin

3 entries

0.163

(phosphate)25

Homo sapiens

-

2 mM Mg2+, 10 mM triphosphate

696296

-

0.33

(phosphate)25

Homo sapiens

-

2 mM Mg2+, 100 mM triphosphate

696296

-

0.055

(phosphate)45

Homo sapiens

-

2 mM Mg2+, 10 mM triphosphate

696296

-

0.12

(phosphate)45

Homo sapiens

-

2 mM Mg2+, 100 mM triphosphate

696296

-

0.064

(phosphate)65

Homo sapiens

-

c2 mM Mg2+, 10 mM triphosphate

696296

-

0.105

(phosphate)65

Homo sapiens

-

c2 mM Mg2+, 100 mM triphosphate

696296

-

1.2

diphosphate

Homo sapiens

-

2 mM Mg2+, 10 mM triphosphate

696296

5.7

diphosphate

Homo sapiens

-

2 mM Mg2+, 100 mM triphosphate

696296

0.0019

nm23-H1

Homo sapiens

-

2 mM Mg2+, 10 mM triphosphate

696296

-

0.0072

nm23-H1

Homo sapiens

-

2 mM Mg2+, 10 mM triphosphate

696296

-

additional information

heparin

Saccharomyces cerevisiae

Q04119

50% inhibition around 1 mg/L

734338

additional information

heparin

Saccharomyces cerevisiae

-

50% inhibition around 1 mg/L

734338

additional information

nm23-H1

Homo sapiens

-

2 mM Mg2+, 60 microM (phosphate)25, 10 mM triphosphate, IC50 is above 0.01 mM

696296

-