3.5.99.6: glucosamine-6-phosphate deaminase

This is an abbreviated version!
For detailed information about glucosamine-6-phosphate deaminase, go to the full flat file.

Reaction

Synonyms

2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol-isomerizing), 2-amino-2-deoxy-D-glucose-6-phosphate ketol isomerase (deaminating), aminodeoxyglucosephosphate isomerase, cGNPDA2-a, cGNPDA2-b, cGNPDA2-c, cGNPDA2-d, EC 5.3.1.10, GlcN-6-P isomerase, GlcN6P deaminase, glucosamine 6-phosphate deaminase, glucosamine 6-phosphate isomerase, glucosamine phosphate deaminase, glucosamine-6-phosphate deaminase, glucosamine-6-phosphate deaminase 1, glucosamine-6-phosphate deaminase 2, glucosamine-6-phosphate deaminase 2 isoform 2, glucosamine-6-phosphate deaminase 2 isoform 3, glucosamine-6-phosphate isomerase, glucosamine-6P deaminase, glucosamine-P isomerase, glucosaminephosphate isomerase, gnd, GNPDA, GNPDA1, GNPDA2, isomerase, glucosamine phosphate, More, NAG1, NagB, NagBBs, NagBEc, oscillin, phoshoglucosamine isomerase, phosphoglucosaminisomerase, SMU.636 protein

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.99 In other compounds

                3.5.99.6 glucosamine-6-phosphate deaminase

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Results	in table
32	Activating Compound
20207	AA Sequence
1	CAS Registry Number
16	Cloned(Commentary)
7	Crystallization (Commentary)
118	Disease/ Diagnostics
1	Expression
17	General Information
6	General Stability
37	Inhibitors
3	kcat/KM [mM/s]
14	Ki Value [mM]
99	KM Value [mM]
9	Metals/Ions
18	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
82	Organism
8	Pathway
53	PDB ID
23	pH Optimum
8	pH Range
1	pH Stability
3	pI Value
2	Posttranslational Modification
32	Protein Variants
22	Purification (Commentary)
7	Reaction
2	Reaction Type
63	Reference
38	Source Tissue
14	Specific Activity [micromol/min/mg]
7	Storage Stability
71	Substrates and Products (Substrate)
23	Subunits
72	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
48	Turnover Number [1/s]

Natural Substrates Products

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of the Enzyme Summary Page.

Natural Substrates Products on EC 3.5.99.6 - glucosamine-6-phosphate deaminase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

12 entries

D-fructose 6-phosphate + NH3

alpha-D-glucosamine 6-phosphate + H2O

Giardia intestinalis

-

-

734837

-

-

r

D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

4 entries

glucosamine 6-phosphate + H2O

fructose 6-phosphate + NH3

4 entries

additional information

?

-

6 entries

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Bacillus subtilis

O35000

-

757097

-

-

?

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Bacillus subtilis 168

O35000

-

757097

-

-

?

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Escherichia coli

P0A759

-

735143, 757097

-

-

?

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Escherichia coli

-

-

757097

-

-

?

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Escherichia coli

P0A759

-

757101

-

-

?

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Gallus gallus

E1C878, I7C3V5, U5LV87, U5LXR4

-

757909

-

-

r

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Giardia intestinalis

-

-

734837

-

-

r

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Homo sapiens

P46926, Q8TDQ7

-

756887

-

-

r

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Homo sapiens

P46926, Q8TDQ7

in standard culture conditions keratinocyte GNPDAs mainly catalyze the reaction from GlcN6P back to Fru6P

756887

-

-

r

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Staphylococcus aureus

A8YZR7

-

753578

-

-

?

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Staphylococcus aureus TCH1516

A8YZR7

-

753578

-

-

?

alpha-D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Staphylococcus aureus USA300

A8YZR7

-

753578

-

-

?

D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Candida albicans

-

-

710931

-

-

?

D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Candida albicans BWP17

-

-

710931

-

-

?

D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Canis lupus familiaris

-

-

671576

-

-

r

D-glucosamine 6-phosphate + H2O

D-fructose 6-phosphate + NH3

Homo sapiens

P46926, Q8TDQ7

-

718986

-

-

?

glucosamine 6-phosphate + H2O

fructose 6-phosphate + NH3

Aspergillus niger

-

the main enzyme in Aspergillus niger cells responsible for rapid glucosamine accumulation during the early stages of growth in a high-citric-acid-yielding medium, the enzyme must compete with 6-phosphofructo-1-kinase for the common substrate fructose 6-phosphate in Aspergillus niger cells, role of glucosamine in the pathway regulation, overview

684638

-

-

r

glucosamine 6-phosphate + H2O

fructose 6-phosphate + NH3

Aspergillus niger A158

-

the main enzyme in Aspergillus niger cells responsible for rapid glucosamine accumulation during the early stages of growth in a high-citric-acid-yielding medium, the enzyme must compete with 6-phosphofructo-1-kinase for the common substrate fructose 6-phosphate in Aspergillus niger cells, role of glucosamine in the pathway regulation, overview

684638

-

-

r

glucosamine 6-phosphate + H2O

fructose 6-phosphate + NH3

Streptococcus mutans

-

-

684212

-

-

?

glucosamine 6-phosphate + H2O

fructose 6-phosphate + NH3

Streptococcus mutans UA159

-

-

684212

-

-

?

additional information

?

-

Bacillus subtilis

-

the enzyme catalyses the first commited step in a biosynthetic pathway leading to amino sugar-nucleotide precursor of bacterial peptidoglycan

648234

-

-

?

additional information

?

-

Escherichia coli

P0A759

the enzyme has a remarkable role as the only allosteric enzyme in the amino-sugar catabolic route

648240

-

-

?

additional information

?

-

Escherichia coli

-

the enzyme has a remarkable role as the only allosteric enzyme in the amino-sugar catabolic route

648240

-

-

?

additional information

?

-

Escherichia coli

P0A759

protein-protein interactions of HPr-NagB, U-PII-NagB, and NanE-NagB activate NagB by increasing the affinity of the enzyme for its substrate, GlcN-6P, and/or increasing the Vmax. NagB, glucosamine 6-phosphate deaminase. Protein-protein interactome for NagB, NagB interacts with numerous proteins in the Escherichia coli cell, overview

757101

-

-

-

additional information

?

-

Homo sapiens

-

the activity of the enzyme in erythrocytes is low, indicating that hexosamine catabolism is not a major source of energy in the erythrocyte

648232

-

-

?

additional information

?

-

Mus musculus

-

enzyme in spermatozoa may play a role during the acrosome reaction

648242

-

-

?