3.5.99.6: glucosamine-6-phosphate deaminase

This is an abbreviated version!
For detailed information about glucosamine-6-phosphate deaminase, go to the full flat file.

Reaction

Synonyms

2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol-isomerizing), 2-amino-2-deoxy-D-glucose-6-phosphate ketol isomerase (deaminating), aminodeoxyglucosephosphate isomerase, cGNPDA2-a, cGNPDA2-b, cGNPDA2-c, cGNPDA2-d, EC 5.3.1.10, GlcN-6-P isomerase, GlcN6P deaminase, glucosamine 6-phosphate deaminase, glucosamine 6-phosphate isomerase, glucosamine phosphate deaminase, glucosamine-6-phosphate deaminase, glucosamine-6-phosphate deaminase 1, glucosamine-6-phosphate deaminase 2, glucosamine-6-phosphate deaminase 2 isoform 2, glucosamine-6-phosphate deaminase 2 isoform 3, glucosamine-6-phosphate isomerase, glucosamine-6P deaminase, glucosamine-P isomerase, glucosaminephosphate isomerase, gnd, GNPDA, GNPDA1, GNPDA2, isomerase, glucosamine phosphate, More, NAG1, NagB, NagBBs, NagBEc, oscillin, phoshoglucosamine isomerase, phosphoglucosaminisomerase, SMU.636 protein

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.99 In other compounds

                3.5.99.6 glucosamine-6-phosphate deaminase

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Results	in table
32	Activating Compound
20207	AA Sequence
1	CAS Registry Number
16	Cloned(Commentary)
7	Crystallization (Commentary)
118	Disease/ Diagnostics
1	Expression
17	General Information
6	General Stability
37	Inhibitors
3	kcat/KM [mM/s]
14	Ki Value [mM]
99	KM Value [mM]
9	Metals/Ions
18	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
82	Organism
8	Pathway
53	PDB ID
23	pH Optimum
8	pH Range
1	pH Stability
3	pI Value
2	Posttranslational Modification
32	Protein Variants
22	Purification (Commentary)
7	Reaction
2	Reaction Type
63	Reference
38	Source Tissue
14	Specific Activity [micromol/min/mg]
7	Storage Stability
71	Substrates and Products (Substrate)
23	Subunits
72	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
2	Temperature Range [°C]
5	Temperature Stability [°C]
48	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.5.99.6 - glucosamine-6-phosphate deaminase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2,5-anhydro mannitol 6-phosphate

Escherichia coli

P0A759

-

648239

2-deoxy-2-amino-D-glucitol 6-phosphate

8 entries

5,5'-dithiobis(2-nitrobenzoate)

Escherichia coli

-

-

648227

alpha-D-glucosamine 6-phosphate

Staphylococcus aureus

A8YZR7

substrate inhibition

753578

Cd2+

Homo sapiens

-

-

648217

Cu2+

Homo sapiens

-

-

648232

cysteine

Homo sapiens

-

-

648217

D-fructose 1,6-diphosphate

Homo sapiens

-

-

648232

D-fructose 6-phosphate

2 entries

D-fructose oxime 6-phosphate

Escherichia coli

P0A759

-

648239

D-glucosamine 6-phosphate

Bacillus subtilis

-

substrate inhibition

669338

D-glucose 6-phosphate

Homo sapiens

-

-

648232

diethyl dicarbonate

Escherichia coli

P0A759

complete inactivation, 2-deoxy-2-amino-D-glucitol 6-phosphate protects

648239

diphosphate

Homo sapiens

-

-

648217

EDTA

2 entries

fluorescamine

Candida albicans

-

-

648224

N-acetylglucosamine 6-phosphate

Homo sapiens

-

-

648232

N3-(4-Methoxyfumaroyl)-L-2,3-diaminopropanoic acid

Bacillus subtilis

-

-

648234

Ni2+

Homo sapiens

-

-

648232

PCMB

3 entries

phosphate

Musca domestica

-

slight inhibition

648219

UDP-N-acetylglucosamine

Homo sapiens

-

slight inhibition at 1.67 mM, slight activation at 0.00167-0.167 mM

648232

Zn2+

2 entries

additional information

3 entries

-

2-deoxy-2-amino-D-glucitol 6-phosphate

Bos taurus

-

-

648236

2-deoxy-2-amino-D-glucitol 6-phosphate

Canis lupus familiaris

-

-

671576

2-deoxy-2-amino-D-glucitol 6-phosphate

Escherichia coli

-

-

648221

2-deoxy-2-amino-D-glucitol 6-phosphate

Escherichia coli

P0A759

-

648239

2-deoxy-2-amino-D-glucitol 6-phosphate

Escherichia coli

-

-

648244

2-deoxy-2-amino-D-glucitol 6-phosphate

Escherichia coli

P0A759

-

667624, 667638

2-deoxy-2-amino-D-glucitol 6-phosphate

Escherichia coli

-

-

667638

2-deoxy-2-amino-D-glucitol 6-phosphate

Giardia intestinalis

-

-

648228

D-fructose 6-phosphate

Escherichia coli

P0A759

-

648239

D-fructose 6-phosphate

Homo sapiens

-

-

648232

EDTA

Homo sapiens

-

-

648217

EDTA

Homo sapiens

-

no inhibition

648232

PCMB

Candida albicans

-

-

648224

PCMB

Homo sapiens

-

inhibits at high concentrations, activates at low concentrations

648217

PCMB

Rattus norvegicus

-

protection by 0.3 mM glucosamine 6-phosphate, no protection by 0.3 mM N-acetylglucosamine 6-phosphate

648223

Zn2+

Escherichia coli

-

tightly bound and slow partial inhibitor

648233

Zn2+

Homo sapiens

-

-

648232

additional information

Canis lupus familiaris

-

no effect by glucose 6-phosphate

671576

-

additional information

Escherichia coli

P0A759

not: alpha and beta O-methyl glycoside of D-fructose 6-phosphate

648239

-

additional information

Escherichia coli

-

not: alpha and beta O-methyl glycoside of D-fructose 6-phosphate

648239

-