3.5.99.2: aminopyrimidine aminohydrolase

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For detailed information about aminopyrimidine aminohydrolase, go to the full flat file.

Reaction

Synonyms

HP1287, TenA, TenA_C, Thi20, Thi20p, thiaminase, thiaminase II, thiaminase type II

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.99 In other compounds

                3.5.99.2 aminopyrimidine aminohydrolase

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Results	in table
4	Activating Compound
10158	AA Sequence
1	CAS Registry Number
9	Cloned(Commentary)
6	Crystallization (Commentary)
8	General Information
18	Inhibitors
2	kcat/KM [mM/s]
8	KM Value [mM]
1	Localization
8	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
23	Organism
6	Pathway
14	PDB ID
9	pH Optimum
1	pH Range
2	Protein Variants
11	Purification (Commentary)
2	Reaction
2	Reaction Type
23	Reference
7	Specific Activity [micromol/min/mg]
43	Substrates and Products (Substrate)
11	Subunits
24	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]
4	Temperature Stability [°C]
6	Turnover Number [1/s]

Engineering

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Engineering on EC 3.5.99.2 - aminopyrimidine aminohydrolase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

F47Y

Helicobacter pylori

O25874

poorly active mutant. At pH 6.0, its activity is absent. Moreover, the enzyme does not present any activity on thiamin degradation

711977

D111A/K115A

Staphylococcus aureus

-

the activity of the monomeric mutant is not significantly altered in comparison to the wild type enzyme

733003