3.5.4.9: methenyltetrahydrofolate cyclohydrolase
This is an abbreviated version!
For detailed information about methenyltetrahydrofolate cyclohydrolase, go to the full flat file.
Word Map on EC 3.5.4.9
-
3.5.4.9
-
gtp
-
purine
-
one-carbon
-
guanosine
-
tetrahydrobiopterin
-
trifunctional
-
bh4
-
5,10-methylenetetrahydrofolate
-
mthfd1
-
10-formyltetrahydrofolate
-
aicar
-
c1-tetrahydrofolate
-
5-aminoimidazole-4-carboxamide
-
folate-dependent
-
10-formyl-thf
-
c1-thf
-
transformylase
-
6.3.4.3
-
sepiapterin
-
formyltransferase
-
dihydroneopterin
-
dopa-responsive
-
5,10-methylene-thf
-
gtpch1
-
2,4-diamino-6-hydroxypyrimidine
-
folate-mediated
-
biopterins
-
drug development
-
medicine
- 3.5.4.9
- gtp
- purine
-
one-carbon
- guanosine
- tetrahydrobiopterin
-
trifunctional
- bh4
- 5,10-methylenetetrahydrofolate
- mthfd1
- 10-formyltetrahydrofolate
- aicar
-
c1-tetrahydrofolate
- 5-aminoimidazole-4-carboxamide
-
folate-dependent
-
10-formyl-thf
-
c1-thf
-
transformylase
-
6.3.4.3
- sepiapterin
-
formyltransferase
- dihydroneopterin
-
dopa-responsive
-
5,10-methylene-thf
- gtpch1
- 2,4-diamino-6-hydroxypyrimidine
-
folate-mediated
- biopterins
- drug development
- medicine
Reaction
Synonyms
5,10-CH+-H4PteGlu cyclohydrolase, 5,10-CH+-THF cyclohydrolase, 5,10-CH=H4 folate synthetase, 5,10-methenyl-H4folate cyclohydrolase, 5,10-methenyl-THF cyclohydrolase, 5,10-methenyltetrahydrofolate cyclohydrolase, 5,10-methenyltetrahydrofolate cyclohydrolase/5,10-methylene tetrahydrofolate dehydrogenase, 5,10-Methenyltetrahydrofolate synthetase, 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, ADE3, bifunctional methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase, bifunctional N5,N10-methylene-H4F dehydrogenase/N5,N10-methenyl-H4F cyclohydrolase, CH+-THF cyclohydrolase, CHF4CH, Citrovorum factor cyclodehydrase, cyclohydrolase, dehydrogenasse-cyclohydrolase-synthetase, DHCH, DHCH 1, DHCH 2, DHCH1, FchA, FolD, formyl-methenyl-methylenetetrahydrofolate synthetase (combined), methenyl-H4F cyclohydrolase, methenyl-tetrahydrofolate cyclohydrolase, methenyl-THF cyclohydrolase, methenylH4F cyclohydrolase, methenyltetrahydrofolate cyclohydrolase, methenyltetrahydrofolate dehydrogenase/cyclohydrolase, methylene tetrahydrofolate dehydrogenase/cyclohydrolase, methylene-tetrahydrofolate dehydrogenase/cyclohydrolase, methyleneH4folate cyclohydrolase, methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase, methylenetetrahydrofolate dehydrogenase/cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase, MIS1, More, mosquito cyclohydrolase, MTHFD1, MTHFD2, MTHFD2L, MTHFDC, N5,N10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase, N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, N5,N10-methylenetetrahydrofolate dehydrogenase/N5,N10-methenyltetrahydrofolate cyclohydrolase, NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase
ECTree
3.5.4.9 methenyltetrahydrofolate cyclohydrolaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 3.5.4.9 - methenyltetrahydrofolate cyclohydrolase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(6R,S)-5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
?
5,10-methenyl-tetrahydrofolate + H2O
10-formyltetrahydrofolate + H+
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrolase activities
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate + ?
cyclodehydrolase activity of MTHFD1
-
-
r
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
-
-
-
-
r
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
-
-
-
-
r
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
-
-
-
-
r
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
-
low activity in the liver
-
-
?
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate + H2O
-
-
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing), EC 3.5.4.9, activity of the enzyme
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing), EC 3.5.4.9, activity of the enzyme
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
bifunctional enzyme exhibits dihydrogenase and cyclohydrolase activities
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
trifunctional enzyme exhibits synthetase, dehydrogenase and cyclohydrolase activities
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
the bifunctional enzyme also shows N5,N10-methylene-H4F dehydrogenase activity, EC 1.5.1.15
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
the bifunctional enzyme also shows N5,N10-methylene-H4F dehydrogenase activity, EC 1.5.1.15
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
r
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methenyltetrahydrofolate + H2O
10-formyltetrahydrofolate
-
-
-
-
?
5,10-methylenetetrahydrofolate + NADP+
5,10-methenyltetrahydrofolate + NADPH + H+
-
methylenetetrahydrofolate dehydrogenase (NADP+), EC 1.5.1.5, activity of the enzyme
-
-
r
5,10-methylenetetrahydrofolate + NADP+
5,10-methenyltetrahydrofolate + NADPH + H+
methylenetetrahydrofolate dehydrogenase (NADP+), EC 1.5.1.5, activity of the enzyme
-
-
r
N5,N10-methenyltetrahydrofolate + H2O
N10-formyltetrahydrofolate
-
-
-
?
N5,N10-methenyltetrahydrofolate + H2O
N10-formyltetrahydrofolate
-
-
-
-
?
additional information
?
-
bifunctional enzyme, channeling efficiency
-
-
?
additional information
?
-
-
the enzyme has a bifunctional DC domain that binds NADP+ and one folate molecule within a single catalytic cleft being part of a trifunctional enzyme, substrate channeling with high efficiency independent of NADP+ substrate binding efficiency
-
-
?
additional information
?
-
-
enzyme deficiency by G1958A polymorphism is involved in spontaneous cervical artery dissections
-
-
?
additional information
?
-
MTHFD1 is a trifunctional enzyme that interconverts tetrahydrofolate derivatives for nucleotide synthesis
-
-
?
additional information
?
-
-
the conversion of formyl- to methylenehydrofolate is rate-limited by the slow conversion by the cyclohydrolase of formyl- to methenyltetrahydrofolate
-
-
?
additional information
?
-
-
dehydrogenase and cyclohydrogenase activities are contained in the single bifunctional protein DHCH1
-
-
?
additional information
?
-
a bifuncitonal enzyme exhibiting N5,N10-methylenetetrahydrofolate dehydrogenase, EC 1.5.1.5, and N5,N10-methenyltetrahydrofolate cyclohydrolase activities
-
-
?
additional information
?
-
-
a bifuncitonal enzyme exhibiting N5,N10-methylenetetrahydrofolate dehydrogenase, EC 1.5.1.5, and N5,N10-methenyltetrahydrofolate cyclohydrolase activities
-
-
?
additional information
?
-
-
a bifuncitonal enzyme exhibiting N5,N10-methylenetetrahydrofolate dehydrogenase, EC 1.5.1.5, and N5,N10-methenyltetrahydrofolate cyclohydrolase activities
-
-
?
additional information
?
-
-
the determined amount of 5-formyltetrahydrofolate formation in the liver is low, possible role in one-carbon metabolism
-
-
?
additional information
?
-
the presence of cytoplasmic and mitochondrial isoforms of a trifunctional dehydrogenase-cyclohydrolase-synthetase support a model wherin the mitochondria can produce fromate which can be used by the cytoplasmic enzymes for the synthesis of purins and for methylation reactions
-
-
?
additional information
?
-
the presence of cytoplasmic and mitochondrial isoforms of a trifunctional dehydrogenase-cyclohydrolase-synthetase support a model wherin the mitochondria can produce fromate which can be used by the cytoplasmic enzymes for the synthesis of purins and for methylation reactions
-
-
?
additional information
?
-
the enzyme is a bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, cf. EC 1.5.1.5
-
-
?
additional information
?
-
-
the enzyme is a bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase, cf. EC 1.5.1.5
-
-
?
additional information
?
-
tetrahydrofolate binding pocket structure analysis, residues 157-163 form a GXGXXXG motif and interact with the substrate, residues Asn157 and highly conserved Ser159 are important, overview
-
-
?
additional information
?
-
-
tetrahydrofolate binding pocket structure analysis, residues 157-163 form a GXGXXXG motif and interact with the substrate, residues Asn157 and highly conserved Ser159 are important, overview
-
-
?
