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3.5.4.6: AMP deaminase

This is an abbreviated version!
For detailed information about AMP deaminase, go to the full flat file.

Word Map on EC 3.5.4.6

Reaction

AMP
+
H2O
=
IMP
 +
NH3

Synonyms

5'-adenosine monophosphate deaminase, 5'-adenylic acid deaminase, 5-adenylate deaminase, 5-adenylic acid deaminase, 5-AMP aminohydrolase, 5-AMP deaminase, adenosine 5-monophosphate deaminase, adenosine 5-phosphate aminohydrolase, adenosine 5-phosphate deaminase, adenosine monophosphate deaminase, adenosine monophosphate deaminase 3, adenosine monophosphate deaminase-1, adenosine-5'-monophosphate deaminase, adenyl deaminase, adenylate aminohydrolase, adenylate deaminase, adenylate desaminase, adenylic acid deaminase, adenylic deaminase, AMP aminase, AMP deaminase, AMP deaminase 3, AMP deaminase H-type, AMP deaminase isoform E, AMP deaminase type 3, AMP deaminase1, AMP-aminohydrolase, AMP-deaminase, AmpD, AMPD1, AMPD2, AMPD3, AMPDA, deaminase, adenylate, embryonic factor 1, EMBRYONIC FACTOR1, Erythrocyte AMP deaminase, FAC1, Heart-type AMPD, muscle AMP deaminase, Myoadenylate deaminase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.6 AMP deaminase

Specific Activity

Specific Activity on EC 3.5.4.6 - AMP deaminase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.008
-
-
0.01
-
enzyme from 40th week-old placenta, in 0.1 M succinate buffer, pH 6.5, at 5 mM substrate (AMP) concentration, at 30°C
0.025
-
enzyme from 33rd week-old placenta, in 0.1 M succinate buffer, pH 6.5, at 5 mM substrate (AMP) concentration, at 30°C
0.037
-
enzyme from 25th week-old placenta, in 0.1 M succinate buffer, pH 6.5, at 5 mM substrate (AMP) concentration, at 30°C
0.077
-
non significant differences in enzyme activity are observed between homogenates from HCC tumor fragments and tumor surrounding fragments of the liver, where the specific activity is about 0.077 micromole/min/mg of protein
0.18 - 1.25
-
-
1100
-
purified enzyme
125
-
delta M90 AMPD3 mutant
1850
-
wild-type AMPD1
2743
-
-
3112
-
DELTA L96 AMPD1 mutant
865
-
wild-type AMPD3
900 - 1100
-
-
additional information