3.5.4.6: AMP deaminase

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For detailed information about AMP deaminase, go to the full flat file.

Reaction

Synonyms

5'-adenosine monophosphate deaminase, 5'-adenylic acid deaminase, 5-adenylate deaminase, 5-adenylic acid deaminase, 5-AMP aminohydrolase, 5-AMP deaminase, adenosine 5-monophosphate deaminase, adenosine 5-phosphate aminohydrolase, adenosine 5-phosphate deaminase, adenosine monophosphate deaminase, adenosine monophosphate deaminase 3, adenosine monophosphate deaminase-1, adenosine-5'-monophosphate deaminase, adenyl deaminase, adenylate aminohydrolase, adenylate deaminase, adenylate desaminase, adenylic acid deaminase, adenylic deaminase, AMP aminase, AMP deaminase, AMP deaminase 3, AMP deaminase H-type, AMP deaminase isoform E, AMP deaminase type 3, AMP deaminase1, AMP-aminohydrolase, AMP-deaminase, AmpD, AMPD1, AMPD2, AMPD3, AMPDA, deaminase, adenylate, embryonic factor 1, EMBRYONIC FACTOR1, Erythrocyte AMP deaminase, FAC1, Heart-type AMPD, muscle AMP deaminase, Myoadenylate deaminase

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.6 AMP deaminase

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Results	in table
52	Activating Compound
8499	AA Sequence
10	Application
1	CAS Registry Number
10	Cloned(Commentary)
2	Crystallization (Commentary)
1392	Disease/ Diagnostics
4	Expression
11	General Information
10	General Stability
27	IC50 Value
130	Inhibitors
1	Ki Value [mM]
35	KM Value [mM]
2	Localization
25	Metals/Ions
26	Molecular Weight [Da]
11	Natural Substrates/ Products (Substrates)
112	Organism
6	Pathway
36	pH Optimum
7	pH Range
7	pH Stability
2	Posttranslational Modification
6	Protein Variants
43	Purification (Commentary)
2	Reaction
2	Reaction Type
106	Reference
99	Source Tissue
28	Specific Activity [micromol/min/mg]
7	Storage Stability
94	Substrates and Products (Substrate)
19	Subunits
101	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
2	Temperature Range [°C]
8	Temperature Stability [°C]

Expression

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Expression on EC 3.5.4.6 - AMP deaminase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

AMP deaminase in the liver is elevated by 4.2fold in models of hepatotoxic injury as compared with controls. In acute hyperammonemia, activity of AMP deaminase increases by 59% in the neocortex. In the hippocampus of hyperammonemic rats, AMP deaminase activity is increased by 48%. Subacute hepatitis leads to 228% increase in AMP deaminase activity

Rattus norvegicus

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711639

during pregnancy the activity of AMP-deaminase in developing human placenta gradually decreases, being in homogenates of mature, term placenta (about 40 weeks of gestation) one fourth to one third of that in homogenates of immature (about 25 weeks of gestation) organ

Homo sapiens

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713244

induction with 0.75 mM isopropyl beta-D-l-thiogalactopyranoside results in an enzyme activity of 1773.9 U/ml

2 entries

induction with 0.75 mM isopropyl beta-D-l-thiogalactopyranoside results in an enzyme activity of 1773.9 U/ml

Aspergillus oryzae

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755821

induction with 0.75 mM isopropyl beta-D-l-thiogalactopyranoside results in an enzyme activity of 1773.9 U/ml

Aspergillus oryzae 3811

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