3.5.4.5: cytidine deaminase

This is an abbreviated version!
For detailed information about cytidine deaminase, go to the full flat file.

Word Map on EC 3.5.4.5

3.5.4.5

hypermutation

immunoglobulin

deamination

ige

b-cells

lymphocyte

leukemia

lymphoma

diversification

class-switched

apobec3g

immunodeficiency

deaminases

uracil

gemcitabine

single-stranded

uridine

isotype

virion

arabinoside

cytarabine

retroviruses

ssdna

glycosylase

lymphomagenesis

deoxyuridine

cd40l

encapsidation

1-beta-d-arabinofuranosylcytosine

deoxycytidylate

c-to-u

blimp-1

nickase

mrna-editing

capecitabine

polypeptide-like

uracil-dna

microhomology

abasic

medicine

5-aza-cdr

drug development

protospacer

diagnostics

5'-deoxy-5-fluorouridine

5\'-dfur

plasmablast

retroelements

zebularine

ara-ctp

t-independent

anti-cd40

unmutated

Reaction

Synonyms

activation-induced cytidine deaminase, AICDA, canine hepatic cyd deaminase, CDA, CDABcald, CDABpsy, CDABsub, CDase, CDD, CR deaminase, cyd deaminase, Cytidine aminohydrolase, cytidine deaminase, cytidine/2'-deoxycytidine aminohydrolase, cytosine nucleoside deaminase, DCD, dCDA, deoxycytidine deaminase, EC 3.5.4.14, mammalian deminase, T-CDA, yeast cytidine deaminase

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.4 In cyclic amidines

3.5.4.5 cytidine deaminase

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Results	in table
18	Activating Compound
25392	AA Sequence
15	Application
2	CAS Registry Number
21	Cloned(Commentary)
13	Crystallization (Commentary)
1877	Disease/ Diagnostics
3	Expression
30	General Information
5	General Stability
241	Inhibitors
3	kcat/KM [mM/s]
27	Ki Value [mM]
132	KM Value [mM]
8	Localization
18	Metals/Ions
68	Molecular Weight [Da]
149	Natural Substrates/ Products (Substrates)
1989	Organism
10	Pathway
67	PDB ID
22	pH Optimum
8	pH Range
5	pH Stability
7	pI Value
23	Protein Variants
44	Purification (Commentary)
3	Reaction
3	Reaction Type
183	Reference
1	Renatured (Commentary)
124	Source Tissue
37	Specific Activity [micromol/min/mg]
21	Storage Stability
434	Substrates and Products (Substrate)
63	Subunits
52	Synonyms
1	Systematic Name
13	Temperature Optimum [°C]
6	Temperature Range [°C]
15	Temperature Stability [°C]
5	Turnover Number [1/s]

KM Value

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KM Value on EC 3.5.4.5 - cytidine deaminase

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0.31 - 3.9

1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine

3 entries

0.33 - 0.66

1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)cytosine

2 entries

0.27 - 0.51

1-beta-D-arabinofuranosylcytosine

2 entries

0.0092 - 0.0957

2',2'-difluorodeoxycytidine

2 entries

0.0726

2',2'-difluorodeoxyuridine

Homo sapiens

i.e. dFdU, variation of plasma ranges between 24.9 and 72.6 microM

695606

0.023 - 1.059

2'-deoxycytidine

10 entries

0.07

2'-fluoro-2'-deoxy-5-iodocytosine arabinoside

Escherichia coli

209653

0.091

2-deoxycytidine

Saccharomyces cerevisiae

209492

0.087

5'-fluoro-5'-deoxycytidine

Escherichia coli

209644

0.11 - 0.113

5,6-Dihydrocytidine

2 entries

0.0477

5-aza-2'-deoxycytidine

Homo sapiens

pH 7.4, 37°C

685915

0.058 - 2.27

5-azacytidine

6 entries

0.087 - 0.1

5-iododeoxycytidine

3 entries

0.13

5-methyl-dCMP

Nocardioides sp.

pH 7.0, 37°C

650635

0.04 - 1.25

5-methylcytidine

4 entries

0.06

5-Methyldeoxycytidine

Escherichia coli

209644

4.2

6-azacytidine

Homo sapiens

209645, 209648

0.14

CMP

Nocardioides sp.

pH 7.0, 37°C

650635

0.0092 - 6.6

cytidine

45 entries

0.089

cytosine

Escherichia coli

209639

0.058 - 0.385

cytosine arabinoside

11 entries

1.475

cytosine beta-D-arabinofuranoside

Brassica oleracea

at pH 7.5 and 27°C

734018

0.089

cytosine deoxyriboside

Escherichia coli

209648, 209660

0.055

dCMP

Nocardioides sp.

pH 7.0, 37°C

650635

0.0075 - 8.53

deoxycytidine

18 entries

additional information

Homo sapiens

kinetics of wild-type and mutant enzymes

689935