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3.5.4.5: cytidine deaminase

This is an abbreviated version!
For detailed information about cytidine deaminase, go to the full flat file.

Word Map on EC 3.5.4.5

Reaction

2'-deoxycytidine
+
H2O
=
2'-deoxyuridine
 +
NH3

Synonyms

activation-induced cytidine deaminase, AICDA, canine hepatic cyd deaminase, CDA, CDABcald, CDABpsy, CDABsub, CDase, CDD, CR deaminase, cyd deaminase, Cytidine aminohydrolase, cytidine deaminase, cytidine/2'-deoxycytidine aminohydrolase, cytosine nucleoside deaminase, DCD, dCDA, deoxycytidine deaminase, EC 3.5.4.14, mammalian deminase, T-CDA, yeast cytidine deaminase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.5 cytidine deaminase

Inhibitors

Inhibitors on EC 3.5.4.5 - cytidine deaminase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(cytidyl)acryloylaminohexanoic acid
-
i.e. CV6
1,10-phenanthroline
-
-
1-(beta-D-ribofuranosyl)-2-pyrimidone
1-(beta-D-ribofuranosyl)-dihydropyrimidine-2-one
1-methyladenosine
-
competitive inhibition
2'-deoxyuridine
-
-
2'-deoxyzebularine 5'-monophosphate
-
-
2-beta-D-ribofuranosyl-1,2,4-triazol-3-one
-
-
2-mercaptoethanol
-
-
2-thio-6-azarudine
-
-
3'-azido-3'-deoxythymidine
-
-
3,4,5,6,tetrahydrozebularine
3,4,5,6-Tetrahydrouridine
3,4-dihydrouridine
3,4-dihydrozebularine
3-deazauridine
4-amino-1-(5-hydroxypentyl)pyrimidin-2(1H)-one
-
-
4-amino-1-hexyl-5,6-dihydropyrimidin-2(1H)-one
-
-
4-hydroxy-1-(beta-D-ribofuranosyl)piperidin-2-one
-
-
5,6-Dihydrouridine
5-(Chloromercuri)cytidine
5-bromodeoxyuridine
5-Bromouridine
-
-
5-fluoro-2'-deoxyuridine
5-fluoropyrimidin-2-one ribonucleoside
-
-
5-fluorouridine
5-fluorozebularine
5-iodo-2'-deoxyuridine
-
-
5-methyluridine
-
-
5-{(1E)-3-[(5-carboxypentyl)amino]-3-oxoprop-1-en-1-yl}-5,6-dihydrocytidine
6-azauridine
-
-
6-thioguanine
-
-
6-[3-(5-cytidyl)acryloylamino]hexanoic acid
-
i.e. CV6
acetone
-
-
adenosine
ara-U
-
-
blasticidin S
-
-
CuSO4
-
complete inhibition
cytidine
-
strong substrate inhibition above 0.5 mM
cytidine monophosphate
-
-
deoxyadenosine
deoxyguanosine
deoxyuridine
diazepinone riboside
dihydrothymidine
-
competitive inhibition
dipicolinic acid
-
-
dithiothreitol
-
-
dTMP
-
0.400 mM 50% inhibition
GTP
-
0.750 mM 85% inhibition
guanosine
HgCl2
-
complete inhibition
mercaptoethanol
-
-
Mersalyl acid
N-ethylmaleimide
p-chloromercuribenzoate
p-mercuribenzoate
phosphapyrimidine
-
-
phosphapyrimidine nucleoside
-
-
pseudouridine
-
-
SDS
-
wild-type tetramer dissociates into enzymatically inactive monomers, without intermediate forms via a non-cooperative transition. Extensive dialysis or dilution of the inativated monomers restores completely the activity. 5-Fluorozebularine disfavours dissociation of the tetramer into subunits in the wild-type enzyme, but not in the mutant enzyme F137W/W113F
tetrahydrouridine
thioglycolic acid
-
0.7 mM 88% relative activity, complete inhibition at 7 mM
thymidine
thymine riboside
uracil arabinoside
-
4.0 mM, 48% inhibition
Urea
-
above 2 M, reversible inactivation
uridine
zebularine
-
inhibits the enzyme, but also DNA methylation, competitive versus 5-aza-2'-deoxycytidine, zebularine affects the antineoplastic action of 5-AZA-CdR on 3T3 cells and V5 cells transduced with CR deaminase gene, overview
Zn2+
-
above 10 mM