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3.5.4.42: N-isopropylammelide isopropylaminohydrolase

This is an abbreviated version!
For detailed information about N-isopropylammelide isopropylaminohydrolase, go to the full flat file.

Reaction

N-isopropylammelide
+
H2O
=
cyanuric acid
+
Isopropylamine

Synonyms

amidase, N-isopropylammelide, AtzC, EC 3.5.99.4, IAIA, N-isopropylammelide amidase, N-isopropylammelide isopropylamidohydrolase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.42 N-isopropylammelide isopropylaminohydrolase

Natural Substrates Products

Natural Substrates Products on EC 3.5.4.42 - N-isopropylammelide isopropylaminohydrolase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
6-(propan-2-ylamino)-1,3,5-triazine-2,4-diol + H2O
1,3,5-triazine-2,4,6-triol + propan-2-amine
show the reaction diagram
-
-
-
-
ir
ammelide + H2O
cyanuric acid + NH3
show the reaction diagram
N-isopropyl ammelide + H2O
cyanuric acid + propan-2-amine
show the reaction diagram
N-isopropylammelide + H2O
?
show the reaction diagram
-
involved in a pathway by which the herbicide atrazine, 2-chloro-4-(ethylamino)-6-(isopopylamino)-1,3,5-triazine, is degraded in bacteria via N-isopropylammelide, 2,4-dihydroxy-6-(isopropylamino)-1,3,5-triazine
-
-
?
additional information
?
-
-
the isolated strain is capable of degrading atrazine. Displacement of the three substituents on the s-triazine ring is mediated by three enzymatic steps encoded by the genes atzA, atzB, and atzC. AtzC stoichiometrically metabolizes N-isopropylammelide to cyanuric acid and N-isopropylamine
-
-
?