3.5.4.41: 5'-deoxyadenosine deaminase

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For detailed information about 5'-deoxyadenosine deaminase, go to the full flat file.

Reaction

Synonyms

DadD, MJ1541

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.41 5'-deoxyadenosine deaminase

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Results	in table
1	Activating Compound
402	AA Sequence
1	Cloned(Commentary)
1	General Information
4	kcat/KM [mM/s]
4	KM Value [mM]
4	Metals/Ions
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
2	Organism
4	Protein Variants
1	Purification (Commentary)
1	Reaction
2	Reference
2	Substrates and Products (Substrate)
2	Subunits
2	Synonyms
1	Systematic Name
3	Temperature Stability [°C]
4	Turnover Number [1/s]

Engineering

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Engineering on EC 3.5.4.41 - 5'-deoxyadenosine deaminase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

C294S

Methanocaldococcus jannaschii

Q58936

the wild-type and the C294S mutant strains are stable after heating for 10 min at 60°C

727779

E150R

Methanocaldococcus jannaschii

Q58936

less thermostable than wild-type enzyme, stable for 10 min at 50°C, showing a significant loss of activity at 60°C. kcat/Km for 5'-deoxyadenosine is 93fold lower than the kcat/Km for the wild-type enzyme

727779

Y136R

Methanocaldococcus jannaschii

Q58936

less thermostable than wild-type enzyme, stable for 10 min at 50°C, showing a significant loss of activity at 60°C. kcat/Km for 5'-deoxyadenosine is 535fold lower than the kcat/Km for the wild-type enzyme

727779

Y136R/E150R

Methanocaldococcus jannaschii

Q58936

less thermostable than wild-type enzyme. kcat/Km for 5'-deoxyadenosine is 290000fold lower than the kcat/Km for the wild-type enzyme

727779