3.5.4.39: GTP cyclohydrolase IV

This is an abbreviated version!
For detailed information about GTP cyclohydrolase IV, go to the full flat file.

Reaction

7,8-dihydroneopterin 2',3'-cyclic phosphate

Synonyms

GTP cyclohydrolase MptA, MptA

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.4 In cyclic amidines

3.5.4.39 GTP cyclohydrolase IV

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
1164	AA Sequence
1	Cloned(Commentary)
4	Inhibitors
1	KM Value [mM]
2	Metals/Ions
3	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
1	Organism
1	Oxidation Stability
6	Pathway
2	pH Optimum
1	pH Range
7	Protein Variants
1	Purification (Commentary)
1	Reaction
1	Reference
6	Substrates and Products (Substrate)
2	Subunits
2	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
3	Temperature Stability [°C]

Engineering

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Engineering on EC 3.5.4.39 - GTP cyclohydrolase IV

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Protein Variants Search

C163S-alkylcysteine

Methanocaldococcus jannaschii

Q58185

when incubated with N-ethylmaleimide, the enzyme loses 67% activity. Iodoacetamide reduces activity by 33%

685163

E50D

Methanocaldococcus jannaschii

Q58185

no effect on specific activity of the enzyme

685163

H101N

Methanocaldococcus jannaschii

Q58185

mutation does not affect the ability of the enzyme to form dihydro-D-neopterin 2',3'-cyclic phosphate nor does it have a reduced amount of iron

685163

H200N/E50D

Methanocaldococcus jannaschii

Q58185

decrease in the specific activity

685163

H293N

Methanocaldococcus jannaschii

Q58185

decrease in the specific activity

685163

H295N

2 entries