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3.5.4.37: double-stranded RNA adenine deaminase

This is an abbreviated version!
For detailed information about double-stranded RNA adenine deaminase, go to the full flat file.

Word Map on EC 3.5.4.37

Reaction

adenine in double-stranded RNA
+
H2O
=
hypoxanthine in double-stranded RNA
 +
NH3

Synonyms

ADAR, ADAR1, ADAR1L, ADAR1S, ADAR2, ADAR2 deaminase, adenosine deaminase acting on RNA 1, adenosine deaminase acting on RNA-1, APOBEC1, bADAR1a, CiADAR1, dADAR, double-stranded RNA adenosine deaminase, double-stranded RNA-specific adenosine deaminase, double-stranded RNA-specific adenosine deaminase 1, double-stranded-RNA-specific adenosine deaminase 1, DRADA1, dsRAD, dsRNA adenosine deaminase, hADAR1, hADAR1a, hADAR2, hADAR2-D

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.37 double-stranded RNA adenine deaminase

Source Tissue

Source Tissue on EC 3.5.4.37 - double-stranded RNA adenine deaminase

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
high expression
Manually annotated by BRENDA team
spatiotemporal expression patterns for ADAR1 and ADAR2 in mouse forebrain. ADAR1 and ADAR2 are broadly distributed in most regions of the mouse forebrain, including the cerebral cortex, hippocampus, and diencephalon. High expression levels are maintained into adulthood. ADAR1 and ADAR2 are expressed in neurons but not astrocytes. ADAR1 mRNA has its lowest expression in the choroid plexus, cortex and hippocampus, while ADAR2 mRNA is least expressed in the cortex and hippocampus, with increased expression in the thalamus
Manually annotated by BRENDA team
spatiotemporal expression patterns for ADAR1 and ADAR2 in mouse forebrain. ADAR1 and ADAR2 are broadly distributed in most regions of the mouse forebrain, including the cerebral cortex, hippocampus, and diencephalon. High expression levels are maintained into adulthood. ADAR1 and ADAR2 are expressed in neurons but not astrocytes. ADAR1 mRNA has its lowest expression in the choroid plexus, cortex and hippocampus, while ADAR2 mRNA is least expressed in the cortex and hippocampus, with increased expression in the thalamus
Manually annotated by BRENDA team
-
low expression in head kidney tissues
Manually annotated by BRENDA team
embryonic
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team
-
low expression
Manually annotated by BRENDA team
dADAR is expressed in the developing nervous system
Manually annotated by BRENDA team
-
high expression
Manually annotated by BRENDA team
-
-
Manually annotated by BRENDA team