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3.5.4.37: double-stranded RNA adenine deaminase

This is an abbreviated version!
For detailed information about double-stranded RNA adenine deaminase, go to the full flat file.

Word Map on EC 3.5.4.37

Reaction

adenine in double-stranded RNA
+
H2O
=
hypoxanthine in double-stranded RNA
+
NH3

Synonyms

ADAR, ADAR1, ADAR1L, ADAR1S, ADAR2, ADAR2 deaminase, adenosine deaminase acting on RNA 1, adenosine deaminase acting on RNA-1, APOBEC1, bADAR1a, CiADAR1, dADAR, double-stranded RNA adenosine deaminase, double-stranded RNA-specific adenosine deaminase, double-stranded RNA-specific adenosine deaminase 1, double-stranded-RNA-specific adenosine deaminase 1, DRADA1, dsRAD, dsRNA adenosine deaminase, hADAR1, hADAR1a, hADAR2, hADAR2-D

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.37 double-stranded RNA adenine deaminase

Localization

Localization on EC 3.5.4.37 - double-stranded RNA adenine deaminase

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
two major isoforms of ADAR1, P150 and P110, named following their molecular weights, are yielded by different RNA splicings. The 150 kDa isoform, translated from exon 1a, is the full length protein that is mainly distributed in the cytosol. The 110 kDa isoform, coded by other alternative first exons and lacking the Z-DNA binding domains, is mainly located in the cell nucleus
Manually annotated by BRENDA team