3.5.4.33: tRNA(adenine34) deaminase
This is an abbreviated version!
For detailed information about tRNA(adenine34) deaminase, go to the full flat file.
Word Map on EC 3.5.4.33
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3.5.4.33
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deamination
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wobble
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anticodons
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heterodimeric
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a-to-i
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deaminases
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chloroplast
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decode
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intellectual
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trna-specific
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disability
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trypanosoma
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trnaarg
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trypanosomatids
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adats
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base-pairing
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cytidine-to-uridine
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post-transcriptionally
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brucei
- 3.5.4.33
-
deamination
-
wobble
-
anticodons
-
heterodimeric
-
a-to-i
- deaminases
- chloroplast
-
decode
-
intellectual
-
trna-specific
-
disability
-
trypanosoma
- trnaarg
-
trypanosomatids
-
adats
-
base-pairing
-
cytidine-to-uridine
-
post-transcriptionally
- brucei
Reaction
Synonyms
ADAT2-ADAT3 complex, ADAT2/3, adenosine-to-inosine tRNA-editing enzyme, AtTadA, spTAD, spTadA, TadA, tadA protein, tadA/ecADAT2, tRNA A:34 deaminase, tRNA adenosine deaminase arginine, tRNA:A34 deaminase, tRNA:adenosine 34 deaminase
ECTree
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Metals Ions
Metals Ions on EC 3.5.4.33 - tRNA(adenine34) deaminase
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Mg2+
P47058; Q9URQ3
optimum concentration2-5 mM, the enzyme does not require any cofactor, except magnesium ions, to deaminate adenosine 34 efficiently in tRNA. The dependence of the enzymatic reaction on magnesium ions probably reflects the need for a correct tRNA architecture
Zn2+
the active site contains a zinc ion, which is coordinated by three strictly conserved amino acids, His53, Cys83, and Cys86
Zn2+
TadA contains endogenous Zn2+ ions. Zn2+ is tetrahedrally coordinated by His52, Cys82, Cys85, and a water
Zn2+
the active site contains a zinc ion coordinated to His53, Cys83 and Cys86
Zn2+
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wild type enzyme coordinates two Zn2+ per heterodimer. Mutation of one of the key Zn2+-coordinating cysteines in TbADAT2 yields a functional enzyme with a single bound zinc