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3.5.4.32: 8-oxoguanine deaminase

This is an abbreviated version!
For detailed information about 8-oxoguanine deaminase, go to the full flat file.

Reaction

8-oxoguanine
+
H2O
=
Urate
+
NH3

Synonyms

8-OGD, 8-oxoGD, Pa0142

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.32 8-oxoguanine deaminase

Natural Substrates Products

Natural Substrates Products on EC 3.5.4.32 - 8-oxoguanine deaminase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
8-oxoguanine + H2O
8-oxoxanthine + NH3
show the reaction diagram
-
8-oxoguanine (8-oxoG), which is formed by the oxidation of guanine within DNA via reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions
-
-
?
8-oxoguanine + H2O
urate + NH3
show the reaction diagram
8-oxoguanine (8-oxoG), which is formed by the oxidation of guanine within DNA via reactive oxygen species. If uncorrected, this modification leads to the incorporation of 8-oxoG:A mismatches and eventually to G:C to T:A transversions
-
-
?