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3.5.4.30: dCTP deaminase (dUMP-forming)

This is an abbreviated version!
For detailed information about dCTP deaminase (dUMP-forming), go to the full flat file.

Reaction

dCTP
+ 2 H2O =
dUMP
+
diphosphate
+
NH3

Synonyms

DCD-DUT, DCD:DUT, dcdB, DCDDUT, dCTP deaminase-dUTP pyrophosphatase, dCTP deaminase-dUTPase, MJ0430

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.30 dCTP deaminase (dUMP-forming)

Systematic Name

Systematic Name on EC 3.5.4.30 - dCTP deaminase (dUMP-forming)

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SYSTEMATIC NAME
IUBMB Comments
dCTP aminohydrolase (dUMP-forming)
Requires Mg2+. Is highly specific for dCTP as substrate as dCMP, CTP, CDP, CMP, cytosine or deoxycytosine are not deaminated. While most bacteria require two enzymes to form dUMP from dCTP (EC 3.5.4.13, dCTP deaminase and EC 3.6.1.23, dUTP diphosphatase), the archaeon Methanocaldococcus jannaschii uses a single enzyme to carry out both functions. This enzyme can also act as a dUTP diphosphatase, but more slowly.