3.5.4.25: GTP cyclohydrolase II
This is an abbreviated version!
For detailed information about GTP cyclohydrolase II, go to the full flat file.
Word Map on EC 3.5.4.25
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3.5.4.25
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riboflavin
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anti-hcv
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lumazine
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guilliermondii
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famata
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gtp-cyclohydrolase
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2,5-diamino-6-ribosylamino-43h-pyrimidinone
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flavinogenic
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6,7-dimethyl-8-ribityllumazine
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pharmacology
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synthesis
- 3.5.4.25
- riboflavin
-
anti-hcv
- lumazine
- guilliermondii
- famata
-
gtp-cyclohydrolase
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2,5-diamino-6-ribosylamino-43h-pyrimidinone
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flavinogenic
- 6,7-dimethyl-8-ribityllumazine
- pharmacology
- synthesis
Reaction
Synonyms
3,4-dihydroxy-2-butanone 4-phosphate synthase, GCH II, GCH II/III, GCH-II, gch2, GCHII, GTP 7,8-8,9-dihydrolase (diphosphate-forming), GTP cyclohydrolase 2, GTP cyclohydrolase II, GTP cyclohydrolase-II, GTP-8-formylhydrolase, GTPCH II, GTPCH-II, guanosine triphosphate cyclohydrolase II, guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase, guanosine-5'-triphosphate cyclohydrolase-II, More, NbRibA, ribA, ribA2, RIBIV, ToxB
ECTree
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General Information
General Information on EC 3.5.4.25 - GTP cyclohydrolase II
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malfunction
metabolism
physiological function
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3,4-dihydroxy 2-butanone 4-phosphate synthase, DHBPS EC 4.1.99.12, and GTP cyclohydrolase-II, GTPCH-II, are the two initial enzymes involved in riboflavin biosynthesis pathway, which is essential for the pathogen
additional information
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bifunctional enzyme with 3,4-dihydroxy 2-butanone 4-phosphate synthase, DHBPS EC 4.1.99.12, and GTP cyclohydrolase-II, GTPCH-II, domains at N- and C-termini, respectively
NbRibA-silenced plants show slightly dwarf phenotypes, levels of endogenous riboflavin and its derivatives FMN and FAD are decreased in NbRibA-silenced Nicotiana benthamiana plants. Silencing of NbRibA compromises not only hypersensitive response cell death, but also the NO and reactive oxygen species production induced by INF1 elicitin and a constitutively active form of NbMEK2, and also induces high susceptibility to oomycete Phytophthora infestans and ascomycete Colletotrichum orbiculare. Compromised radical production and hypersensitive response cell death induced by INF1 in NbRibA-silenced leaves are rescued by adding riboflavin, FMN or FAD
GCH II catalyzes the first committed step in the riboflavin biosynthetic pathway
metabolism
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GTP cyclohydrolase II catalyzes the first dedicated step in the biosynthesis of riboflavin
metabolism
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3,4-dihydroxy 2-butanone 4-phosphate synthase, DHBPS EC 4.1.99.12, and GTP cyclohydrolase-II, GTPCH-II, are the two initial enzymes involved in riboflavin biosynthesis pathway, which is essential for the pathogen
metabolism
the bifunctional enzyme, guanosine triphosphate cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase, participates in the biosynthesis of flavin
metabolism
GTP cyclohydrolase II catalyzes the first committed step in the biosynthesis of riboflavin
metabolism
the enzyme is essential for pathogens. The enzyme can regulate its catalytic activity depending on the redox environment
metabolism
the enzyme is involved in riboflavin biosynthesis and in biosynthesis of toxoflavin (a phytotoxin that contributes the virulence of this phytopathogen)
metabolism
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GCH II catalyzes the first committed step in the riboflavin biosynthetic pathway
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metabolism
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the enzyme is essential for pathogens. The enzyme can regulate its catalytic activity depending on the redox environment
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metabolism
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the enzyme is involved in riboflavin biosynthesis and in biosynthesis of toxoflavin (a phytotoxin that contributes the virulence of this phytopathogen)
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