3.5.4.16: GTP cyclohydrolase I

This is an abbreviated version!
For detailed information about GTP cyclohydrolase I, go to the full flat file.

Reaction

Synonyms

dihydroneopterin triphosphate synthase, FelE, folE, GCH, GCH-1, GCH1, GCHI, GCYH-IA, GCYH-IB, GTP 8-formylhydrolase, GTP CHase I, GTP cyclohydrolase, GTP cyclohydrolase 1, GTP cyclohydrolase I, GTP cyclohydrolase IA, GTP cyclohydrolase IB, GTP cyclohydrolase-1, GTP-CH, GTP-CH-I, GTP-CH1, GTP-cyclohydrolase 1, GTP-cyclohydrolase I, GTPCH, GTPCH I, GTPCH-1, GTPCH1, GTPCHI, guanosine 5'-triphosphate-cyclohydrolase I, guanosine triphosphate 8-deformylase, guanosine triphosphate cyclohydrolase, guanosine triphosphate cyclohydrolase 1, guanosine triphosphate cyclohydrolase I, guanosine-5'-triphosphate cyclohydrolase 1, hydrolase, guanosine triphosphate cyclo-, MptA, Punch, Punch protein

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.4 In cyclic amidines

                3.5.4.16 GTP cyclohydrolase I

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Results	in table
17	Activating Compound
48611	AA Sequence
9	Application
1	CAS Registry Number
30	Cloned(Commentary)
10	Crystallization (Commentary)
1199	Disease/ Diagnostics
5	Expression
34	General Information
1	General Stability
170	Inhibitors
10	Ki Value [mM]
39	KM Value [mM]
14	Localization
24	Metals/Ions
41	Molecular Weight [Da]
58	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
273	Organism
15	Pathway
286	PDB ID
39	pH Optimum
1	pH Range
2	pH Stability
3	Posttranslational Modification
68	Protein Variants
31	Purification (Commentary)
11	Reaction
2	Reaction Type
118	Reference
2	Renatured (Commentary)
86	Source Tissue
29	Specific Activity [micromol/min/mg]
5	Storage Stability
161	Substrates and Products (Substrate)
30	Subunits
120	Synonyms
1	Systematic Name
24	Temperature Optimum [°C]
1	Temperature Range [°C]
6	Temperature Stability [°C]
5	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.5.4.16 - GTP cyclohydrolase I

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

17beta-estradiol

Rattus norvegicus

-

can regulate GTPCH gene expression via transcriptional mechanisms

670416

H2O2

Homo sapiens

-

0.1 mM H2O2 is the optimum concentration for the activation of GTPCHI

699378

interferon-gamma

Homo sapiens

-

GCH1 expression is strongly induced by a mixture of interleukin-1beta, tissue necrosis factor-alpha, and interferon-gamma released by microglia under brain-damaging conditions

701141

-

interleukin-1beta

Homo sapiens

-

GCH1 expression is strongly induced by a mixture of interleukin-1beta, tissue necrosis factor-alpha, and interferon-gamma released by microglia under brain-damaging conditions

701141

-

L-phenylalanine

4 entries

lipolysaccharide

Mus musculus

Q05915

commercially isolated from Escherichia coli serotype 026:B6, activates and upregulates the enzyme in adipose tissue, but in cultured 3T3-L1 adipocytes lipolysaccharide addition only increases the enzyme expression level in presence of TNFalpha and interferon gamma, overview

667769

-

tissue necrosis factor-alpha

Homo sapiens

-

GCH1 expression is strongly induced by a mixture of interleukin-1beta, tissue necrosis factor-alpha, and interferon-gamma released by microglia under brain-damaging conditions

701141

-

additional information

8 entries

-

L-phenylalanine

Homo sapiens

-

feedback regulation via L-phenylalanine

699378

L-phenylalanine

Rattus norvegicus

-

feed-forward stimulation at subsaturating concentration of GTP mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP

657288

L-phenylalanine

Rattus norvegicus

-

feed-forward stimulation at subsaturating concentration of GTP mediated by GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, in complex with the enzyme, binding site structure

657188

L-phenylalanine

Rattus norvegicus

-

stimulates the enzyme via mediation of GFRP which forms a complex with the enzyme

656261

additional information

Drosophila melanogaster

-

GTP cyclohydrolase I is activated by phosphorylation with protein kinase C or A

698830

-

additional information

Homo sapiens

-

S81 phosphorylation enhances GTPCH-1 enzyme activity

719308

-

additional information

Mus musculus

-

GTPCH expression is regulated by inflammatory stimuli, in association with reduced expression of GTP cyclohydrolase feedback regulatory protein

698891

-

additional information

Mus musculus

-

reduction in GTP-CH1 regulatory protein expression following proinflammatory stimulation is necessary for optimal GTP-CH1 activity

701372

-

additional information

Rattus norvegicus

-

estrogen-triggered activation of GTP cyclohydrolase 1 gene expression, time course in transfected cells and mechanism, overview

670416

-

additional information

Rattus norvegicus

-

lipopolysaccharide application by injection increases enzyme expression in kidney, but not in liver and lung

667025

-

additional information

Rattus norvegicus

P22288

GTP-CH 1 mRNA and protein expression is unaltered by renal ischemia-reperfusion

684313

-

additional information

Rattus norvegicus

-

GTP-CH 1 mRNA and protein expression is unaltered by renal ischemia-reperfusion

684313

-