3.5.4.10: IMP cyclohydrolase

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For detailed information about IMP cyclohydrolase, go to the full flat file.

Word Map on EC 3.5.4.10

3.5.4.10

integrins

itgav

ecm-receptor

faicar

alpha2beta1

tfase

medicine

drug development

Reaction

5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

Synonyms

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide tranformylase/IMP cyclohydrolase, AF1811, AICAR tranformylase/IMP cyclohydrolase, AICAR transformylase/IMP cyclohydrolase, AICAR transformylase/inosine 5'-monophosphate cyclohydrolase, AICAR-FT/IMP-CHase, AICAR-transformylase/IMP cyclohydrolase, ATIC, atic-1, IMP synthetase, IMPCH, IMPCHase, inosinate cyclohydrolase, inosine 5'-monophosphate cyclohydrolase, inosine monophosphate cyclohydrolase, inosinicase, ITGA2, MjPurO, MthPurO, PurH, PurH2, PurH2-type IMP cyclohydrolase, PurO, PurO-type IMP cyclohydrolase, TK0430

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.4 In cyclic amidines

3.5.4.10 IMP cyclohydrolase

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Results	in table
2	Activating Compound
37909	AA Sequence
3	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
397	Disease/ Diagnostics
1	Expression
12	General Information
4	IC50 Value
26	Inhibitors
2	kcat/KM [mM/s]
3	Ki Value [mM]
26	KM Value [mM]
1	Metals/Ions
13	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
40	Organism
8	Pathway
58	PDB ID
12	pH Optimum
2	pH Range
3	pH Stability
1	pI Value
1	Posttranslational Modification
30	Protein Variants
16	Purification (Commentary)
6	Reaction
1	Reaction Type
39	Reference
19	Source Tissue
10	Specific Activity [micromol/min/mg]
2	Storage Stability
45	Substrates and Products (Substrate)
19	Subunits
44	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
8	Temperature Stability [°C]
23	Turnover Number [1/s]

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Application on EC 3.5.4.10 - IMP cyclohydrolase

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drug development

2 entries

medicine

Homo sapiens

P31939

determination of differentially expressed genes in HT-29 cells, both after short treatment with methotrexate and after the resistance to methotrexate has been established. Enzyme as well as survivin and inosine monophosphate dehydrogenase type II are upregulated

668561