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3.5.4.1: cytosine deaminase

This is an abbreviated version!
For detailed information about cytosine deaminase, go to the full flat file.

Word Map on EC 3.5.4.1

Reaction

cytosine
+
H2O
=
Uracil
 +
NH3

Synonyms

A3DE, APOBEC1, APOBEC3, APOBEC3G, CD, CDA, CDase, codA, CodA protein, Cytosine aminohydrolase, cytosine deaminase, cytosine deaminase I, cytosine deaminase II, cytosine deaminase P, cytosine deaminase S, cytosine deaminase Y, Fca1p, FCY1, isocytosine deaminase, yCD, Zn2+CDase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.4 In cyclic amidines
                3.5.4.1 cytosine deaminase

Temperature Stability

Temperature Stability on EC 3.5.4.1 - cytosine deaminase

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TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
stable for a week
37
-
the hyaluronan binding domain of tumor necrosis factor alpha-stimulated gene-6-cytosine deaminase fusion protein retains 20% of its initial enzyme activity after 24 h, 12% after 48 h, and 6% after 124 h at 37°C. In contrast, the activity of cytosine deaminase decreases rapidly at 37°C, and retains only about 5% of initial activity after 24 h
42
-
the melting temperature of cytosine deaminase is at 42°C
45
-
extremely thermo-unstable, loses more than 85% activity when heated for 10 min at pH 7
70
-
after treating for 10 min at pH 7, 75% activity remains
73
-
extremely thermostable