3.5.4.1: cytosine deaminase
This is an abbreviated version!
For detailed information about cytosine deaminase, go to the full flat file.
Word Map on EC 3.5.4.1
-
3.5.4.1
-
cytidine
-
deaminases
-
5-fluorocytosine
-
deamination
-
prodrugs
-
virion
-
hypermutation
-
viruses
-
5-fluorouracil
-
apolipoprotein
-
retroviruses
-
suicide
-
uracil
-
retroviral
-
apobecs
-
single-stranded
-
antiretroviral
-
polypeptide-like
-
mrna-editing
-
g-to-a
-
bystander
-
activation-induced
-
retrotransposons
-
anti-hiv-1
-
proviral
-
retroelements
-
lentiviruses
-
encapsidation
-
ganciclovir
-
deoxycytidine
-
retrotransposition
-
ssdna
-
fiv
-
samhd1
-
cullin
-
minus-strand
-
replication-competent
-
gene-directed
-
sivmac
-
medicine
-
line-1
-
hsv-tk
-
vpr
-
gdept
-
non-ltr
-
molecular biology
-
xenotropic
-
analysis
-
pharmacology
-
biotechnology
-
trim5alpha
-
diagnostics
-
proviruses
-
nickase
-
agriculture
-
single-cycle
-
elongins
- 3.5.4.1
- cytidine
- deaminases
- 5-fluorocytosine
-
deamination
-
prodrugs
- virion
-
hypermutation
- viruses
- 5-fluorouracil
-
apolipoprotein
- retroviruses
-
suicide
- uracil
-
retroviral
-
apobecs
-
single-stranded
-
antiretroviral
-
polypeptide-like
-
mrna-editing
-
g-to-a
-
bystander
-
activation-induced
-
retrotransposons
-
anti-hiv-1
-
proviral
-
retroelements
- lentiviruses
-
encapsidation
- ganciclovir
- deoxycytidine
-
retrotransposition
- ssdna
- fiv
- samhd1
-
cullin
-
minus-strand
-
replication-competent
-
gene-directed
- sivmac
- medicine
-
line-1
-
hsv-tk
- vpr
-
gdept
-
non-ltr
- molecular biology
-
xenotropic
- analysis
- pharmacology
- biotechnology
- trim5alpha
- diagnostics
- proviruses
-
nickase
- agriculture
-
single-cycle
-
elongins
Reaction
Synonyms
A3DE, APOBEC1, APOBEC3, APOBEC3G, CD, CDA, CDase, codA, CodA protein, Cytosine aminohydrolase, cytosine deaminase, cytosine deaminase I, cytosine deaminase II, cytosine deaminase P, cytosine deaminase S, cytosine deaminase Y, Fca1p, FCY1, isocytosine deaminase, yCD, Zn2+CDase
ECTree
Advanced search results
General Information
General Information on EC 3.5.4.1 - cytosine deaminase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
metabolism
-
human mitochondrial and nuclear DNA are edited by APOBEC3A. The degree of editing is much greater in patients lacking the uracil DNA-glycolyase gene
physiological function
for woodchuck hepatitis virus mAPOBEC3 is operative
physiological function
mHBV (mouse transgenic model of HBV replication) is edited in vivo by mAPOBEC1 (mA1) and not mAPOBEC3
physiological function
-
porcine A3 is tested toward their antiretroviral activity against porcine endogenous retrovirus (PERV) and murine leukemia virus (MuLV) using novel single-round reporter viruses. The porcine A3Z2, A3Z3 and A3Z2-Z3 mRNAs are packaged into PERV particles and inhibit PERV replication in a dose-dependent manner. The antiretroviral effect correlate with editing by the porcine A3s with a trinucleotide preference for 5' TGC for A3Z2 and A3Z2-Z3 and 5' CAC for A3Z3
physiological function
residues His62, Cys91, and Cys94 are very important in coordinating the zinc cation. The bound water molecule and Glu64 are crucial in the formation of the reactant-metal binding state, the subsequent chemical reaction, and the cleavage of the product-metal binding state. Asn51, Glu64, and Asp155 form hydrogen bonds with the product and block the product from moving away from the protein. Phe114 and Trp152 play a dual role of gating and guiding in the pocket of exit
physiological function
-
residues His62, Cys91, and Cys94 are very important in coordinating the zinc cation. The bound water molecule and Glu64 are crucial in the formation of the reactant-metal binding state, the subsequent chemical reaction, and the cleavage of the product-metal binding state. Asn51, Glu64, and Asp155 form hydrogen bonds with the product and block the product from moving away from the protein. Phe114 and Trp152 play a dual role of gating and guiding in the pocket of exit
-