3.5.4.1: cytosine deaminase
This is an abbreviated version!
For detailed information about cytosine deaminase, go to the full flat file.
Word Map on EC 3.5.4.1
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3.5.4.1
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cytidine
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deaminases
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5-fluorocytosine
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deamination
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prodrugs
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virion
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hypermutation
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viruses
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5-fluorouracil
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apolipoprotein
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retroviruses
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suicide
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uracil
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retroviral
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apobecs
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single-stranded
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antiretroviral
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polypeptide-like
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mrna-editing
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g-to-a
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bystander
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activation-induced
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retrotransposons
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anti-hiv-1
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proviral
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retroelements
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lentiviruses
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encapsidation
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ganciclovir
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deoxycytidine
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retrotransposition
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ssdna
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fiv
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samhd1
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cullin
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minus-strand
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replication-competent
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gene-directed
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sivmac
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medicine
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line-1
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hsv-tk
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vpr
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gdept
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non-ltr
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molecular biology
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xenotropic
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analysis
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pharmacology
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biotechnology
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trim5alpha
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diagnostics
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proviruses
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nickase
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agriculture
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single-cycle
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elongins
- 3.5.4.1
- cytidine
- deaminases
- 5-fluorocytosine
-
deamination
-
prodrugs
- virion
-
hypermutation
- viruses
- 5-fluorouracil
-
apolipoprotein
- retroviruses
-
suicide
- uracil
-
retroviral
-
apobecs
-
single-stranded
-
antiretroviral
-
polypeptide-like
-
mrna-editing
-
g-to-a
-
bystander
-
activation-induced
-
retrotransposons
-
anti-hiv-1
-
proviral
-
retroelements
- lentiviruses
-
encapsidation
- ganciclovir
- deoxycytidine
-
retrotransposition
- ssdna
- fiv
- samhd1
-
cullin
-
minus-strand
-
replication-competent
-
gene-directed
- sivmac
- medicine
-
line-1
-
hsv-tk
- vpr
-
gdept
-
non-ltr
- molecular biology
-
xenotropic
- analysis
- pharmacology
- biotechnology
- trim5alpha
- diagnostics
- proviruses
-
nickase
- agriculture
-
single-cycle
-
elongins
Reaction
Synonyms
A3DE, APOBEC1, APOBEC3, APOBEC3G, CD, CDA, CDase, codA, CodA protein, Cytosine aminohydrolase, cytosine deaminase, cytosine deaminase I, cytosine deaminase II, cytosine deaminase P, cytosine deaminase S, cytosine deaminase Y, Fca1p, FCY1, isocytosine deaminase, yCD, Zn2+CDase
ECTree
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Activating Compound
Activating Compound on EC 3.5.4.1 - cytosine deaminase
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1-ethyl-3-(3-dimethylaminopropyl)carbodiimide
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1.0 mM + glycine methyl ester, relative activity 102%
2-mercaptoethanol
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1 mM, relative activity 108%
alpha,alpha'-dipyridyl
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1 mM, relative activity 104%
dGMP
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1.0 mM, substrate cytosine, relative activity 109%
ATP
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1.0 mM, substrate cytosine, relative activity 105%, substrate 5-methylcytosine relative activity 113%
L-aspartic acid
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10.0 mM, relative activity 158%
L-Glutamic acid
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10.0 mM, relative activity 135%
L-hydroxyproline
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10.0 mM, relative activity 141%
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conjugation of poly-L-lysine to cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy, e.g. by a 50times higher cellular uptake than that of control molecules in human breast MDA-MB-231 cancer cells and increase stability after uptake into cells, uptake and intracellular distribution, mechanisms, overview
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additional information
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low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview
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additional information
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during hypoxia in Y87-1 and Y87-2 cells, a hypoxia-responsive element regulates expression of the cytosine deaminase gene and facilitates the conversion of 5-fluorocytosine to 5-fluorouracil
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