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3.5.3.6: arginine deiminase

This is an abbreviated version!
For detailed information about arginine deiminase, go to the full flat file.

Word Map on EC 3.5.3.6

Reaction

L-arginine
+
H2O
=
L-citrulline
 +
NH3

Synonyms

ADI, ArcA, arcA-1, arcA-2, arginine deiminase, arginine dihydrolase, arginine-degrading enzyme, citrulline iminase, deiminase, arginine, L-arginine deiminase, LADI, lymphocyte blastogenesis inhibitory factor, More, PaADI, PAD, PAD2, peptidylarginine deiminase, PpADI, Streptococcal acid glycoprotein

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.3 In linear amidines
                3.5.3.6 arginine deiminase

Metals Ions

Metals Ions on EC 3.5.3.6 - arginine deiminase

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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(NH4)2SO4
-
optimal activity in presence of 2.0 M, 48% of the activation with NaCl
Ca2+
the concentration of calcium required for in vitro activity is at least 10 times higher than cellular calcium concentrations (i.e., 0.0001-0.010 mM). Calcium binding occurs in an ordered fashion. A calcium switch (calcium binding sites 3, 4, and 5) controls the overall calcium dependence of the enzyme
CdCl2
-
optimal activity in presence of 5.0 M, 52% of the activation with NaCl
Co2+
-
required, maximal activity at 0.5 mM CoCl2
K+
-
dependency on K+ ions as a cofactor
MgCl2
increases the activity 8fold at 20 mM
Na2HPO4
-
optimal activity in presence of 2.0 M, 77% of the activation with NaCl
Na2SO4
-
optimal activity in presence of 1.5 M, 39% of the activation with NaCl
NaBr
-
optimal activity in presence of 3.0 M, 24% of the activation with NaCl
NaCl
-
optimal activity in presence of 3.5 M
RbCl
-
optimal activity in presence of 5.0 M, 53% of the activation with NaCl
additional information
-
PAD is not a metalloenzyme