3.5.3.11: agmatinase

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For detailed information about agmatinase, go to the full flat file.

Reaction

Synonyms

AGM-1, AGMAT, agmatinase, agmatinase-like protein, agmatine ureohydrolase, Alr2310, APL, AUH, HVO_2299, MJ0309, N130D variant of arginase type I, Proclavaminic acid amidino hydrolase, SpeB

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.3 In linear amidines

                3.5.3.11 agmatinase

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Results	in table
4	Activating Compound
12374	AA Sequence
1	CAS Registry Number
8	Cloned(Commentary)
3	Crystallization (Commentary)
37	Disease/ Diagnostics
2	Expression
8	General Information
1	General Stability
24	Inhibitors
5	kcat/KM [mM/s]
4	Ki Value [mM]
18	KM Value [mM]
1	Localization
13	Metals/Ions
12	Molecular Weight [Da]
15	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
39	Organism
6	Pathway
83	PDB ID
5	pH Optimum
2	pH Range
18	Protein Variants
7	Purification (Commentary)
1	Reaction
1	Reaction Type
39	Reference
28	Source Tissue
1	Specific Activity [micromol/min/mg]
1	Storage Stability
23	Substrates and Products (Substrate)
8	Subunits
27	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Temperature Stability [°C]
12	Turnover Number [1/s]

pH Range

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pH Range on EC 3.5.3.11 - agmatinase

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

6.5 - 10

Methanocaldococcus jannaschii

Q57757

no activity is detected at pH 6.5 and the measured activity steadily increases to pH 10.0. Higher pH values are tested but the observation of activity is dependent on the buffer used and are not reported here. Agmatine shows no hydrolysis in the pH 10 and 11 buffers and assay conditions used

726980

9.5 - 12.5

Pyrococcus horikoshii

-

pH 9.5: about 50% of maximal activity, pH 12.5: about 85% of maximal activity

664200