3.5.2.B2: (+)-gamma-lactamase
This is an abbreviated version!
For detailed information about (+)-gamma-lactamase, go to the full flat file.
Word Map on EC 3.5.2.B2
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3.5.2.B2
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drug development
-
synthesis
-
abacavir
-
enantioselective
-
sulfolobus
-
microbacterium
-
carbovir
-
biuret
-
racemic
-
enantiomeric
-
solfataricus
-
carbocyclic
-
nucleoside
-
japonicum
-
bradyrhizobium
-
industry
- 3.5.2.B2
- drug development
- synthesis
- abacavir
-
enantioselective
-
sulfolobus
-
microbacterium
-
carbovir
- biuret
-
racemic
-
enantiomeric
- solfataricus
-
carbocyclic
- nucleoside
- japonicum
-
bradyrhizobium
- industry
Reaction
Synonyms
(+) gamma-lactamase, (+)-gamma-lactamase, BJ6T_02120, Daci_0225, Delm, FDB1, FGSG_00079, FPSE_08124, IHL, isochorismatase-like hydrolase, Mh33H4-5540, MhIHL, Mhpg, RutB, Sslact, SSO2810, Sspg, SYJ322B5
ECTree
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Reference on EC 3.5.2.B2 - (+)-gamma-lactamase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Xue, T.Y.; Xu, G.C.; Han, R.Z.; Ni, Y.
Soluble expression of (+)-gamma-lactamase in Bacillus subtilis for the enantioselective preparation of abacavir precursor
Appl. Biochem. Biotechnol.
176
1687-1699
2015
Delftia acidovorans (A9BPK4), Delftia acidovorans DSM 14801 (A9BPK4)
Ren, L.; Zhu, S.; Shi, Y.; Gao, S.; Zheng, G.
Enantioselective resolution of gamma-lactam by a novel thermostable type II (+)-gamma-lactamase from the hyperthermophilic archaeon Aeropyrum pernix
Appl. Biochem. Biotechnol.
176
170-184
2015
Aeropyrum pernix
Wang, J.; Zhu, Y.; Zhao, G.; Zhu, J.; Wu, S.
Characterization of a recombinant (+)-gamma-lactamase from Microbacterium hydrocarbonoxydans which provides evidence that two enantiocomplementary gamma-lactamases are in the strain
Appl. Microbiol. Biotechnol.
99
3069-3080
2015
Microbacterium hydrocarbonoxydans (A0A077AY47)
Gao, S.; Zhu, S.; Huang, R.; Lu, Y.; Zheng, G.
Efficient synthesis of the intermediate of abacavir and carbovir using a novel (+)-gamma-lactamase as a catalyst
Bioorg. Med. Chem. Lett.
25
3878-3881
2015
Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA 6
Kettle, A.J.; Carere, J.; Batley, J.; Benfield, A.H.; Manners, J.M.; Kazan, K.; Gardiner, D.M.
A gamma-lactamase from cereal infecting Fusarium spp. catalyses the first step in the degradation of the benzoxazolinone class of phytoalexins
Fungal Genet. Biol.
83
1-9
2015
Fusarium graminearum (I1R9E4), Fusarium pseudograminearum (K3VFR8), Fusarium pseudograminearum CS3096 (K3VFR8), Fusarium graminearum ATCC MYA-4620 (I1R9E4)
Zhu, S.; Huang, R.; Gao, S.; Li, X.; Zheng, G.
Discovery and characterization of a second extremely thermostable (+)-gamma-lactamase from Sulfolobus solfataricus P2
J. Biosci. Bioeng.
121
484-490
2015
Saccharolobus solfataricus (Q97V26), Saccharolobus solfataricus DSM 1617 (Q97V26)
Gao, S.; Zhu, S.; Huang, R.; Li, H.; Wang, H.; Zheng, G.
Engineering the enantioselectivity and thermostability of a (+)-?-lactamase from Microbacterium hydrocarbonoxydans for kinetic resolution of Vince lactam (2-azabicyclo[2.2.1]hept-5-en-3-one)
Appl. Environ. Microbiol.
84
e01780-17
2018
Microbacterium hydrocarbonoxydans (A0A0K0XHU0)
Gao, S.; Huang, R.; Zhu, S.; Li, H.; Zheng, G.
Identification and characterization of a novel (+)-gamma-lactamase from Microbacterium hydrocarbonoxydans
Appl. Microbiol. Biotechnol.
100
9543-9553
2016
Microbacterium hydrocarbonoxydans (A0A0K0XHU0), Microbacterium hydrocarbonoxydans
Gao, S.; Lu, Y.; Li, Y.; Huang, R.; Zheng, G.
Enhancement in the catalytic activity of Sulfolobus solfataricus P2 (+)-?-lactamase by semi-rational design with the aid of a newly established high-throughput screening method
Appl. Microbiol. Biotechnol.
103
251-263
2019
Saccharolobus solfataricus (P95896), Saccharolobus solfataricus ATCC 35092 (P95896)
Wang, J.; Zhao, H.; Zhao, G.; Chen, D.; Tao, Y.; Wu, S.
Enhancing the atypical esterase promiscuity of the gamma-lactamase Sspg from Sulfolobus solfataricus by substrate screening
Appl. Microbiol. Biotechnol.
103
4077-4087
2019
Saccharolobus solfataricus (P95896), Saccharolobus solfataricus ATCC 35092 (P95896)
Wang, J.; Zhu, J.; Wu, S.
Immobilization on macroporous resin makes E. coli RutB a robust catalyst for production of (-) Vince lactam
Appl. Microbiol. Biotechnol.
99
4691-4700
2015
Escherichia coli (A0A5E8GM52), Escherichia coli JM109 (A0A5E8GM52)
Li, H.; Zhu, S.; Zheng, G.
Promiscuous (+)-gamma-lactamase activity of an amidase from nitrile hydratase pathway for efficient synthesis of carbocyclic nucleosides intermediate
Bioorg. Med. Chem. Lett.
28
1071-1076
2018
Rhodococcus erythropolis (Q7DKE4), Rhodococcus erythropolis R4 (Q7DKE4)
Littlechild, J.A.
Enzymes from Extreme Environments and Their Industrial Applications
Front. Bioeng. Biotechnol.
3
161
2015
Saccharolobus solfataricus, Saccharolobus solfataricus MT4
Zhu, S.; Zheng, G.
Dynamic kinetic resolution of Vince lactam catalyzed by gamma-lactamases a mini-review
J. Ind. Microbiol. Biotechnol.
45
1017-1031
2018
Aeropyrum pernix, Bradyrhizobium japonicum, Burkholderia cepacia, Delftia acidovorans, Escherichia coli, Pseudomonas fluorescens, Ralstonia solanacearum, Rhodococcus erythropolis, Rhodococcus globerulus, Saccharolobus solfataricus, Nocardia farcinica, Delftia sp., Microbacterium hydrocarbonoxydans, Pseudomonas granadensis, Pseudomonas granadensis B6, Bradyrhizobium japonicum USDA 6, Pseudomonas fluorescens ENZA 22, Ralstonia solanacearum ENZA 20, Rhodococcus erythropolis PR4, Delftia sp. CGMCC 5755
Su, Y.; Gao, S.; Li, H.; Zheng, G.
Enantioselective resolution of gamma-lactam utilizing a novel (+)-gamma-lactamase from Bacillus thuringiensis
Proc. Biochem.
72
96-104
2018
Bacillus thuringiensis (Q6HKW3)
-
Gao, S.; Zhou, Y.; Zhang, W.; Wang, W.; Yu, Y.; Mu, Y.; Wang, H.; Gong, X.; Zheng, G.; Feng, Y.
Structural insights into the ?-lactamase activity and substrate enantioselectivity of an isochorismatase-like hydrolase from Microbacterium hydrocarbonoxydans
Sci. Rep.
7
44542
2017
Microbacterium hydrocarbonoxydans (A0A0K0XHU0), Microbacterium hydrocarbonoxydans (E3SVR9), Microbacterium hydrocarbonoxydans
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